High-frequency stimulation selectively blocks different types of fibers in frog sciatic nerve.
High-frequency stimulation selectively blocks different types of fibers in frog sciatic nerve.
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DOI：
10.1109/tnsre.2011.2163082
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Butera RJ
中科院分区：
文献类型：
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作者：
Joseph L;Butera RJ
高频交流电(HFAC)刺激可可逆性阻断多种神经的传导。然而，与对有髓纤维的模拟和实验不同的是，我们实验室先前在海螺(Aplysia)上的实验工作发现，无髓纤维的频率和阻断阈值之间存在非单调关系。为了解决这一差异，我们研究了高频交流波形对青蛙坐骨神经复合动作电位的影响。对神经的最大刺激产生复合动作电位，该复合动作电位由A纤维和C纤维组成，与有髓纤维和无髓纤维的反应相对应。在我们的研究中，在频率为5-50 kHz，幅度为0.1-1 mA的范围内，HFAC波形在A纤维和C纤维中诱导可逆性传导阻滞。虽然A纤维表现出文献中所观察到的单调增加的阈值行为，但C纤维表现出非单调关系，类似于在海兔的无髓纤维中观察到的。在应用HFAC波形的过程中，在有髓和无髓纤维中观察到的这种不同的阻断行为对选择性刺激和疼痛治疗领域具有不同的意义。
Conduction block using high frequency alternating current (HFAC) stimulation has been shown to reversibly block conduction through various nerves. However, unlike simulations and experiments on myelinated fibers, prior experimental work in our lab on the sea-slug, Aplysia, found a nonmonotonic relationship between frequency and blocking thresholds in the unmyelinated fibers. To resolve this discrepancy, we investigated the effect of HFAC waveforms on the compound action potential of the sciatic nerve of frogs. Maximal stimulation of the nerve produces a compound action potential consisting of the A-fiber and C-fiber components corresponding to the myelinated and unmyelinated fibers’ response. In our study, HFAC waveforms were found to induce reversible block in the A-fibers and C-fibers for frequencies in the range of 5–50 kHz and for amplitudes from 0.1–1 mA. Although the A-fibers demonstrated the monotonically increasing threshold behavior observed in published literature, the C-fibers displayed a nonmonotonic relationship, analogous to that observed in the unmyelinated fibers of Aplysia. This differential blocking behavior observed in myelinated and unmyelinated fibers during application of HFAC waveforms has diverse implications for the fields of selective stimulation and pain management.