Physiological aspects of pig kidney xenotransplantation and implications for management following transplant.
Physiological aspects of pig kidney xenotransplantation and implications for management following transplant.
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DOI：
10.1111/xen.12743
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发表时间：
2022-05
影响因子：
3.9
通讯作者：
Judd, Eric
中科院分区：
文献类型：
--
作者：
Hansen-Estruch, Christophe;Cooper, David K. C.;Judd, Eric
通过基因改造，物种间成功的器官移植现在是可能的。本文旨在全面概述人类、灵长类动物和猪之间肾功能的差异和相似之处，为猪同种异体移植到人异种移植做准备。肾脏作为机体内环境稳定的主要捍卫者，充当生理反馈系统的传感器、效应器和调节器。考虑将猪肾植入人体受体时对每个系统的预期影响。讨论主题包括：解剖学、整体肾功能、钠和水处理、肾激素产生和对循环激素的反应、酸碱平衡以及钙和磷处理。根据现有数据，尽管存在一些障碍，但预计猪肾与人体生理学相容。
Successful organ transplantation between species is now possible, using genetic modifications. This manuscript aims to provide a comprehensive overview of the differences and similarities in kidney function between humans, primates, and pigs, in preparation for pig-allograft to human xenotransplantation. The kidney, as the principal defender of body homeostasis, acts as a sensor, effector, and regulator of physiologic feedback systems. Considerations are made for anticipated effects on each system when a pig kidney is placed into a human recipient. Discussion topics include: anatomy, global kidney function, sodium and water handling, kidney hormone production and response to circulating hormones, acid-base balance, and calcium and phosphorus handling. Based on available data, pig kidneys are anticipated to be compatible with human physiology, despite a few barriers.
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影响因子：
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