A case of synchronous high-grade cervical intraepithelial neoplasia and metastatic squamous cell carcinomas of unknown primary in rectum.
A case of synchronous high-grade cervical intraepithelial neoplasia and metastatic squamous cell carcinomas of unknown primary in rectum.
复制标题
直肠高级别上皮内瘤变与原发灶不明的转移性鳞状细胞癌同时发生一例。
DOI：
10.1111/jog.14798
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Fujiwara H.
中科院分区：
文献类型：
--
作者：
Orisaka S;Nakamura M;Obata T;Iwadare J;Mizumoto Y;Fujiwara H.
我们报告一个同时发生于直肠的高级别子宫颈上皮内瘤变（CIN）和转移性鳞状细胞癌（SCC）的病例。一名74岁女性通过宫颈活检诊断为CIN 3。磁共振成像显示直肠外壁有两个肿块。经直肠活检证实为SCC。手术治疗时，分别确定了直肠中的CIN3和SCC。病理学分析显示，SCC在直肠浆膜中观察到，而不是粘膜，表明这些肿瘤是转移性SCC。基因分析显示CIN 3中HPV31阳性，TP53突变，直肠SCC中HPV16阳性。治疗前检查未发现直肠转移性SCC的原发部位。我们诊断患者同时患有CIN3和直肠原发不明的转移性SCC。在这种情况下，基因分析有助于阐明CIN3与SCC之间的关系。
We report a case of synchronous high‐grade cervical intraepithelial neoplasia (CIN) and metastatic squamous cell carcinomas (SCCs) of unknown primary in the rectum. A 74‐year‐old woman was diagnosed with CIN3 by biopsy of the uterine cervix. Magnetic resonance imaging showed two masses in the outer rectal wall. They were diagnosed as SCCs by transrectal biopsy from one mass. On surgical treatment, CIN3 and SCCs in the rectum were identified, respectively. Pathological analysis revealed that SCCs were observed in serosa of the rectum, not mucosa, indicating that these tumors were metastatic SCCs. Gene analysis showed HPV31‐positive andTP53mutation in CIN3, and HPV16‐positive in rectal SCCs. Pretreatment examination did not detect the primary site of metastatic SCCs in the rectum. We diagnosed the patient with synchronous CIN3 and metastatic SCCs of unknown primary in the rectum. In this case, gene analysis was useful to clarify the relationship between CIN3 and SCCs.