Bone marrow-derived cells from male donors can compose endometrial glands in female transplant recipients
Bone marrow-derived cells from male donors can compose endometrial glands in female transplant recipients
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DOI：
10.1016/j.ajog.2009.07.026
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发表时间：
2009-12-01
影响因子：
9.8
通讯作者：
Inoue, Masaki
中科院分区：
文献类型：
--
作者：
Ikoma, Tomomi;Kyo, Satoru;Inoue, Masaki
目的：对于月经周期中人子宫内膜的连续再生，子宫内膜干细胞被认为是分化的子宫内膜腺细胞的供应者。为了阐明子宫内膜干细胞的起源，我们检测了接受男性供体骨髓移植的患者的子宫内膜中供体来源的细胞的存在。研究设计：获得激素替代治疗后活检的子宫内膜标本，并使用靶向X或Y染色体的荧光原位杂交分析进行检测。所有受者的供者来源的Y染色体阳性的子宫内膜细胞，占0.6-8.4%的腺上皮细胞和8.2-9.8%的间质细胞。结论：供者来源的细胞可以组成受体的子宫内膜，甚至是异性的子宫内膜。这些结果表明骨髓干细胞具有意想不到的可塑性，同时也是子宫内膜干细胞的潜在来源。
OBJECTIVE: For continuous regeneration of human endometrium in menstrual cycles, endometrial stem cells are assumed to supply differentiating endometrial glandular cells. To elucidate the origin of endometrial stem cells, we examined the presence of donor-derived cells in endometria from patients who received bone marrow transplantation from male donors.STUDY DESIGN: Endometrial specimens biopsied after hormone replacement therapy were obtained and examined using fluorescent in situ hybridization analysis targeting X or Y chromosomes.RESULTS: All recipients had donor-derived Y chromosome-positive endometrial cells, accounting for 0.6-8.4% of glandular epithelial cells and 8.2-9.8% of stromal cells. Most of the endometrial glands were chimeric, consisting of both donor-derived and recipient cells.CONCLUSION: Donor-derived cells are capable of composing endometrium in recipients, even those of the opposite sex. These results suggest unexpected plasticity of bone marrow stem cells as well as a potential origin of endometrial stem cells.