Repeatability of Quantitative Parameters Derived From Diffusion Tensor Imaging in Patients With Glioblastoma Multiforme
Repeatability of Quantitative Parameters Derived From Diffusion Tensor Imaging in Patients With Glioblastoma Multiforme
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DOI：
10.1002/jmri.21732
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发表时间：
2009-05-01
影响因子：
4.4
通讯作者：
Vredenburgh, James J.
中科院分区：
文献类型：
--
作者：
Paldino, Michael J.;Barboriak, Daniel;Vredenburgh, James J.
目的：为了量化的可重复性表观扩散系数（ADC）和分数各向异性（FA）在多形性胶质母细胞瘤patients with glioblastoma multiforme.Materials and Methods：IRB的批准和知情同意书，获得了这项健康保险的便携性和责任法案兼容的研究。16例多形性胶质母细胞瘤患者在两个时间点进行了MR成像，没有间隔干预。ADC和FA图与对比增强和液体衰减反转恢复（FLAIR）图像体积配准。结果：肿瘤相关增强（TRE）和FLAIR信号异常（FSA）的平均ADC值和平均FA值在两种TRE内的重复观察结果高度一致ADC值：r = 0.947，P < 0.0001; FA值：r = 0.947，P < 0.0001; FSA值：r = 0.979，P< 0.0001; FA值：r = 0.972，P< 0.0001。在TRE。测量的变化的重复性系数和95%置信区间（CI）为0.104 x 10（-3）mm（2）S（-1）和7.4%（ADC）以及0.0196和13.9%（FA）。分别在FSA内，测量的重复性系数和95% CI分别为0.071 x 10（-3）mm（2）S（-1）和5.2%（ADC）以及0.0159和8.7%（FA）。为了检测平均ADC的10%变化，需要9例（TRE）和6例（FSA）患者的样本量。平均FA相同的变化将需要样本量的21（TRE）和10（FSA）patients.Conclusion：治疗后的变化大于重复性系数或95%CI的变化是不太可能与ADC和FA的测量变异。
Purpose: To quantify the repeatability of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in patients with glioblastoma multiforme.Materials and Methods: IRB approval and informed consent were obtained for this Health Insurance portability and Accountability Act-compliant study. Sixteen patients with glioblastoma multiforme underwent MR imaging at two time points without interval intervention. ADC and FA maps were registered to the contrast-enhanced and fluid-attenuated inversion recovery (FLAIR) image volumes. Volumes of tumor-related enhancement (TRE) and FLAIR signal abnormality (FSA) were defined using a semiautomated segmentation technique.Results: Repeated observations of mean ADC and mean FA were highly consistent within both TRE (ADC: r = 0.947,P < 0.0001; FA: r = 0.947, P < 0.0001) and FSA (ADC: r = 0.979, P< 0.0001; FA: r = 0.972, P< 0.0001). Within TRE. repeatability coefficients and 95% confidence intervals (CIs) for change measured 0.104 x 10(-3) mm(2)S(-1) and 7.4% (ADC) and 0.0196 and 13.9% (FA). respectively. Within FSA, repeatability coefficients and 95% Cl for change measured 0.071 x 10(-3) mm(2)S(-1) and 5.2% (ADC) and 0.0159 and 8.7% (FA), respectively. To detect 10% changes in mean ADC, sample sizes of nine (TRE) and six (FSA) patients would be required. The same change in mean FA would require sample sizes of 21 (TRE) and 10 (FSA) patients, respectively.Conclusion: Changes after therapy greater than the repeatability coefficient or 95% Cl for change are unlikely to be related to variability in the measurement of ADC and FA.