CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions
CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions
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DOI：
10.1111/j.1440-1746.2005.03933.x
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发表时间：
2006-02-01
影响因子：
4.1
通讯作者：
Park, CS
中科院分区：
文献类型：
--
作者：
Kim, HS;Lee, JS;Park, CS
背景：近年来的研究表明，CDX-2在胃的肠上皮化生和胃癌中表达。为探讨CDX-2在肠型胃癌发生中的作用，采用免疫组化方法检测CDX-2在158例胃癌及癌前病变中的表达。根据Padova国际分类法，患者被分为组织病理学亚组：60例低度非侵袭性肿瘤，55例高度非侵袭性肿瘤，45例侵袭性膀胱型腺癌。CDX-2的表达在非肿瘤性胃粘膜，包括肠上皮化生也进行了评估，在包括在组织学sect.Results的区域：CDX-2的表达定位于上皮细胞核中的肠上皮化生或不典型增生和癌，其作为一个转录调节器的作用是一致的。所有病例的正常粘膜中均未观察到CDX-2反应。CDX-2在低级别、高级别和膀胱型腺癌中的阳性表达率分别为73.3%、85.5%和91.1%。肠上皮化生胃粘膜中，阳性率为89.7%。CDX-2表达细胞在肠上皮化生中比在异型增生和癌中更普遍。CDX-2的表达表现出统计学上显着的正相关性增加的异型增生和cancer.Conclusions：这些研究结果表明，CDX-2在胃癌的表达可能是胃癌发生的进展的标志物，它的激活可能代表一个早期事件。(C)2005年Blackwell Publishing Asia Pty Ltd.
Background: Recent studies have demonstrated that CDX-2 is expressed in the intestinal metaplasia of the stomach and intestinal-type gastric cancer. To address the role of CDX-2 in carcinogenesis of gastric carcinomas of intestinal type, the expression of CDX-2 in gastric carcinoma and precursor lesions were examined using immunohistochemistry.Methods: A total of 160 specimens diagnosed as gastric carcinomas or non-invasive neoplasia from 158 patients were analyzed for CDX-2 expression by immunochemical methods. Patients were classified into histopathologic subgroups according to the Padova international classification: 60 cases of low-grade non-invasive neoplasia, 55 cases of high grade, and 45 cases of invasive intestinal-type adenocarcinoma. The CDX-2 expression in non-neoplastic gastric mucosa including intestinal metaplasia was also evaluated in the areas included in the histologic sections.Results: The CDX-2 expression was localized in the epithelial cell nuclei in the area of intestinal metaplasia with or without dysplasia and carcinoma, consistent with its role as a transcriptional regulator. No CDX-2 reactivity was noted in the normal mucosa in all cases. The CDX-2 expression was detected in 73.3% of low-grade cases, 85.5% of high-grade cases and 91.1% of intestinal-type adenocarcinoma cases. In the gastric mucosa with intestinal metaplasia, 89.7% of the samples were positive. The CDX-2-expressing cells in intestinal metaplasia were more prevalent than in dysplasia and carcinoma. Expression of CDX-2 showed a statistically significant positive correlation with increasing grade of dysplasia and carcinoma.Conclusions: These findings suggest that CDX-2 expression in stomach cancer may be a marker of the progression of gastric carcinogenesis, and that its activation may represent an early event. (C) 2005 Blackwell Publishing Asia Pty Ltd.