DECREASED MAP KINASE-ACTIVITY IN HUMAN GASTRIC ADENOCARCINOMA
DECREASED MAP KINASE-ACTIVITY IN HUMAN GASTRIC ADENOCARCINOMA
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DOI：
10.1006/bbrc.1995.2069
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发表时间：
1995-07-26
影响因子：
3.1
通讯作者：
HOLIAN, O
中科院分区：
文献类型：
--
作者：
ATTEN, MJ;ATTAR, BM;HOLIAN, O
我们通过检查丝裂原激活蛋白激酶 (MAPK) 在正常和转化的人胃组织中的作用来研究与胃癌相关的细胞信号转导事件。与组织学正常胃组织相比，在腺癌的膜部分中发现 MAPK 丰度和活性显着降低，而在这两种组织类型的胞质部分中未发现 MAPK 的显着变化。这些发现表明 MAPK 丰度和活性的降低与人胃腺癌正常生长控制的丧失有关。 (C) 1995 学术出版社
We investigated the cellular signaling events involved in gastric cancer by examining the role of mitogen activated protein kinase (MAPK) in normal and transformed human gastric tissue. A significant loss in both MAPK abundance and activity was found in the membrane fractions of the adenocarcinomas when compared to the histologically normal gastric tissue, while no significant alteration in MAPK was seen in the cytosolic fractions from these two tissue types. These findings suggest that reduction in MAPK abundance and activity are associated with loss of normal growth control in human gastric adenocarcinoma. (C) 1995 Academic Press, Inc.