Reproduction-Immunity Trade-Offs in Insects.
Reproduction-Immunity Trade-Offs in Insects.
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DOI：
10.1146/annurev-ento-010715-023924
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发表时间：
2016
影响因子：
23.8
通讯作者：
Wolfner MF
中科院分区：
文献类型：
--
作者：
Schwenke RA;Lazzaro BP;Wolfner MF
免疫防御和繁殖是需要生理和能量的过程，已经观察到在各种雌性昆虫中进行权衡。生殖努力的增加会导致免疫力下降，反过来，感染和免疫系统的激活也会减少生殖产出。这种权衡可以表现在生理层面(个体内部)和进化层面(群体中个体之间的遗传差异)。资源分配模型假设，这种权衡是由于对一个或多个有限资源的竞争而产生的，我们假设多效性信号机制调节生殖和免疫过程之间的资源分配。我们研究了保幼激素、20-羟基蜕皮激素和胰岛素/胰岛素样生长因子信号在调节卵子发生和免疫系统活动中的作用，并提出了一个可能机械地调节这种权衡的信号网络。最后，我们在生态和进化的背景下讨论了这种权衡的含义。
Immune defense and reproduction are physiologically and energetically demanding processes and have been observed to trade off in a diversity of female insects. Increased reproductive effort results in reduced immunity, and reciprocally, infection and activation of the immune system reduce reproductive output. This trade-off can manifest at the physiological level (within an individual) and at the evolutionary level (genetic distinction among individuals in a population). The resource allocation model posits that the trade-off arises because of competition for one or more limiting resources, and we hypothesize that pleiotropic signaling mechanisms regulate allocation of that resource between reproductive and immune processes. We examine the role of juvenile hormone, 20-hydroxyecdysone, and insulin/insulin-like growth factor-like signaling in regulating both oogenesis and immune system activity, and propose a signaling network that may mechanistically regulate the trade-off. Finally, we discuss implications of the trade-off in an ecological and evolutionary context.