Chromatin as a eukaryotic template of genetic information
Chromatin as a eukaryotic template of genetic information
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DOI：
10.1016/s0955-0674(02)00324-1
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发表时间：
2002-06-01
影响因子：
7.5
通讯作者：
Cavalli, G
中科院分区：
文献类型：
--
作者：
Cavalli, G
在真核生物中，染色质是遗传所必需的。染色质结构有时在DNA上是“上位的”，并赋予相同的DNA序列不同的遗传状态或赋予不相关的DNA序列相同的功能状态。这已被记录在最近的各种各样的研究集中在酵母交配型的调节，Polycomb和trithorax组蛋白的功能，真核着丝粒和新着丝粒的规格，和基因组印迹。
In eukaryotes, chromatin is essential for heredity. Chromatin architecture is sometimes 'epistatic' over the DNA and imparts a different heritable state to the same DNA sequence or the same functional state to unrelated DNA sequences. This has been documented recently in a wide variety of studies focused on regulation of the yeast mating type, the function of Polycomb and trithorax group proteins, the specification of eukaryotic centromeres and neocentromeres, and genomic imprinting.