ANTI-PLASMIN INHIBITOR .5. STRUCTURES OF NOVEL DIMERIC ECKOLS ISOLATED FROM THE BROWN ALGA ECKLONIA-KUROME OKAMURA
ANTI-PLASMIN INHIBITOR .5. STRUCTURES OF NOVEL DIMERIC ECKOLS ISOLATED FROM THE BROWN ALGA ECKLONIA-KUROME OKAMURA
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DOI：
10.1248/cpb.37.2438
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发表时间：
1989-09-01
影响因子：
1.7
通讯作者：
TAKAHASHI, M
中科院分区：
文献类型：
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作者：
FUKUYAMA, Y;KODAMA, M;TAKAHASHI, M
6，6“-Bieckol（1）、2-O-（2，4，6-trihydroxyphenyl）-6，6”-bieckol（4）和8，8“-bieckol（2）是一种具有二苯并-1，4-二恶英骨架的双多酚化合物，已从褐色的黑鳞海葵Ecklonia kurome Okamura中分离得到。它们的结构已被确定为在C-6和C-8位置通过芳基-芳基键连接的eckol的二聚体。已经检测了它们对抗纤溶酶（α 2-巨球蛋白和α 2-纤溶酶抑制剂）和一些蛋白酶的抑制作用。
6,6''-Bieckol (1), 2-O-(2,4,6-trihydroxyphenyl)-6,6''-bieckol (4), and 8,8''-bieckol (2), bispolyphenols with a dibenzo-1,4-dioxin skeleton, have been isolated as potent anti-plasmin inhibitors from the brown alga Ecklonia kurome Okamura. Their structures have been determined to be dimers of eckol linked at the C-6 and C-8 positions, through an aryl-aryl bond on the basis of spectral data. Their inhibitory actions on anti-plasmins (.alpha.2-macroglobulin and .alpha.2-plasmin inhibitor) and some proteases have been examined.