Lifetime low-level exposure to environmental lead and children's emotional and behavioral development at ages 11-13 years - The Port Pirie Cohort Study
Lifetime low-level exposure to environmental lead and children's emotional and behavioral development at ages 11-13 years - The Port Pirie Cohort Study
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DOI：
10.1093/oxfordjournals.aje.a009883
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发表时间：
1999-04-15
影响因子：
5
通讯作者：
Tong, SL
中科院分区：
文献类型：
--
作者：
Burns, JM;Baghurst, PA;Tong, SL
皮里港队列研究是第一项前瞻性监测终生血铅暴露与儿童经历的情绪和行为问题患病率之间的关联的研究。来自澳大利亚皮里港铅冶炼社区的322名11-13岁儿童获得了铅暴露数据以及儿童行为检查表上的评级。终生平均血铅浓度大于15微克/分升的男童平均行为问题总分(95%可信区间)为28.7(24.6~32.8)，低于低血铅水平男童的21.1(17.5~24.8)。女孩的平均得分(95%CI)为29.7(25.3-34.2)和18.0(14.7-21.3)，在控制了一些混淆变量后，包括儿童的家庭环境质量(家庭环境测量评估)、母亲的精神病理和儿童的智商，回归模型预测，假设终身血铅暴露从10增加到30微克/分升，男孩的外化行为问题分数将增加3.5(95%CI 1.6-5.4)。女孩增加1.8人(95%CI-0.1至11.1)。内在化行为问题得分在女孩中预计上升2.1(95%可信区间为0.0~4.2)，而在男孩中仅上升0.8(95%可信区间为-0.9~2.4)。
The Port Pirie Cohort Study is the first study to monitor prospectively the association between lifetime blood lead exposure and the prevalence of emotional and behavioral problems experienced by children. Lead exposure data along with ratings on the Child Behavior Checklist were obtained for 322 11-13-year-old children from the lead smelting community of Port Pirie, Australia. Mean total behavior problem score (95% confidence interval (CI)) for boys whose lifetime average blood lead concentration was above 15 mu g/dl was 28.7 (24.6-32.8) compared with 21.1 (17.5-24.8) in boys with lower exposure levels. The corresponding mean scores (95% CI) for girls were 29.7 (25.3-34.2) and 18.0 (14.7-21.3), After controlling for a number of confounding variables, including the quality of the child's HOME environment (assessed by Home Observation for Measurement of the Environment), maternal psychopathology, and the child's IQ, regression modeling predicted that for a hypothetical increase in lifetime blood lead exposure from 10 to 30 mu g/dl, the externalizing behavior problem score would increase by 3.5 in boys (95% CI 1.6-5.4), and by 1.8 (95% CI -0.1 to 11.1) in girls. Internalizing behavior problem scores were predicted to rise by 2.1 (95% CI 0.0-4.2) in girls but by only 0.8 (95% CI -0.9 to 2.4) in boys.