Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: preeclampsia
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: preeclampsia
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DOI：
10.1016/j.ajog.2010.01.024
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发表时间：
2010-03-01
影响因子：
9.8
通讯作者：
Dr Rogers
中科院分区：
文献类型：
--
作者：
Dr Yogev;Dr Chen;Dr Rogers
目的：本研究的目的是研究关联空腹C肽，体重指数（BMI），孕妇血糖与先兆子痫的风险在一个多中心的多国study.Study设计：我们进行了二次分析的盲观察队列研究。受试者在妊娠24-32周时接受75 g口服葡萄糖耐量试验。先兆子痫与空腹C-肽，体重指数和母体血糖的关联进行了评估，采用多元逻辑回归分析和调整潜在的混杂因素。结果：在21,364名妇女谁被纳入分析，5.2%的先兆子痫。1 SD空腹C肽升高的先兆子痫校正比值比（0.87微克/升），体重指数（5.1 kg/m2），空腹（6.9 mg/dL），1小时（30.9 mg/dL）和2小时血糖（23.5 mg/dL）为1.28（95%置信区间[CI]，1.20-1.36），1.60（95%CI，1.60-1.71）、1.08（95%CI，1.00-1.16）、1.19（95%CI，1.11-1.28）和1.21（95%CI，1.13-1.30）。母体血糖水平（低于糖尿病）与先兆子痫的相关性较弱，特别是在调整空腹C肽和BMI后。
OBJECTIVE: The purpose of this study was to examine associations of fasting C-peptide, body mass index (BMI), and maternal glucose with the risk of preeclampsia in a multicenter multinational study.STUDY DESIGN: We conducted a secondary analysis of a blinded observational cohort study. Subjects underwent a 75-g oral glucose tolerance test at 24-32 weeks' gestation. Associations of preeclampsia with fasting C-peptide, BMI, and maternal glucose were assessed with the use of multiple logistic regression analyses and adjustment for potential confounders.RESULTS: Of 21,364 women who were included in the analyses, 5.2% had preeclampsia. Adjusted odds ratios for preeclampsia for 1 SD higher fasting C-peptide (0.87 ug/L), BMI (5.1 kg/m(2)), and fasting (6.9 mg/dL), 1-hour (30.9 mg/dL), and 2-hour plasma glucose (23.5 mg/dL) were 1.28 (95% confidence interval [CI], 1.20-1.36), 1.60 (95% CI, 1.60-1.71), 1.08 (95% CI, 1.00-1.16), 1.19 (95% CI, 1.11-1.28), and 1.21 (95% CI, 1.13-1.30), respectively.CONCLUSION: Results indicate strong, independent associations of fasting C-peptide and BMI with preeclampsia. Maternal glucose levels (below diabetes mellitus) had weaker associations with preeclampsia, particularly after adjustment for fasting C-peptide and BMI.