Crohn's disease in Olmsted County, Minnesota, 1940-1993: Incidence, prevalence, and survival
Crohn's disease in Olmsted County, Minnesota, 1940-1993: Incidence, prevalence, and survival
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DOI：
10.1016/s0016-5085(98)70421-4
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发表时间：
1998-06-01
期刊：
影响因子：
29.4
通讯作者：
Zinsmeister, AR
中科院分区：
文献类型：
--
作者：
Loftus, EV;Silverstein, MD;Zinsmeister, AR
背景与目的：世界上许多中心都报道了克罗恩病发病率的增加，但北美基于人群的数据很少。我们研究了明尼苏达州奥姆斯特德县克罗恩病的发病率和流行率，并检查了发病率和生存率的时间趋势。方法：1970 ~ 1993年诊断为克罗恩病的居民为发病病例，1991年1月1日活着的克罗恩病居民为流行病例。先前研究的病例再次得到证实。根据1990年美国白人人口普查数据进行了调整。用泊松回归模型评估发病率趋势。将诊断后的存活率与美国中北部白人的预期存活率进行比较。结果：在1940年至1993年期间，确定了225例发病率，调整后的发病率为每10万人年5.8例。1991年1月1日，有145名居民患有克罗恩病，调整后的患病率为每10万人133人，比1980年高出46%。1964年以前的发病率明显低于1989-1993年。观察生存率低于预期（P = 0.007）。结论：自20世纪70年代以来，克罗恩病的发病率趋于稳定，其发病率高于以往。自1980年以来，患病率增加了46%。总生存率略有下降。
Background & Aims: Many centers worldwide have reported an increased incidence of Crohn's disease, but population-based data in North America are sparse. We studied the incidence and prevalence of Crohn's disease in Olmsted County, Minnesota, and examined temporal trends in incidence and survival. Methods: Residents diagnosed with Crohn's disease between 1970 and 1993 were incidence cases, and residents with Crohn's disease who were alive on January 1, 1991, were prevalence cases. Cases from previous studies were reconfirmed. Rates were adjusted using 1990 U.S. Census figures for whites. Incidence trends were evaluated with a Poisson regression model. Survival from diagnosis was compared with that expected for U.S. north-central whites. Results: Between 1940 and 1993, 225 incidence cases were identified, for an adjusted incidence rate of 5.8 per 100,000 person-years. On January 1, 1991, there were 145 residents with Crohn's disease, an adjusted prevalence rate of 133 per 100,000, 46% higher than that seen in 1980. Incidence rates before 1964 were significantly lower than those of 1989-1993. Observed survival was less than expected (P = 0.007). Conclusions: The incidence of Crohn's disease has stabilized since the 1970s at a rate higher than that seen previously. Prevalence has increased by 46% since 1980. Overall survival is slightly decreased.