Differential effects of intracerebroventricular glucagon-like peptide-1 on feeding and energy expenditure regulation
Differential effects of intracerebroventricular glucagon-like peptide-1 on feeding and energy expenditure regulation
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DOI：
10.1016/s0196-9781(98)00033-3
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发表时间：
1998-01-01
期刊：
影响因子：
3
通讯作者：
Strader, CD
中科院分区：
文献类型：
--
作者：
Hwa, JJ;Ghibaudi, L;Strader, CD
脑室内 (ICV) 施用胰高血糖素样肽-1-(7-37) 酰胺 (GLP-1) 已被证明可以调节食物和水的摄入。目前的研究进一步描述了 ICV GLP-1 在瘦肉和肥胖动物能量平衡调节中的作用。在肥胖和瘦Zucker大鼠中，在夜间周期的前2小时内，单次ICV输注GLP-1（1-30μg）导致相对于盐水对照的剂量依赖性食物摄入减少和呼吸商降低。在肥胖的 Zucker 大鼠中，在 30 μg 剂量下，食物摄入量比对照组减少了 73 +/- 11%，而在瘦大鼠中则观察到适度的减少 45 +/- 18%。尽管 GLP-1 使食物摄入量大幅减少，但肥胖 Zucker 大鼠的夜间耗氧量并没有出现代偿性减少。有趣的是，在瘦 Zucker 大鼠中给予低剂量的 GLP-1（1 μg），对食物摄入的影响很小，但在夜间周期的前 2 小时内，导致 O-2 消耗量增加 19 +/- 7%。这些数据表明，中枢 GLP-1 可能是控制瘦和肥胖 Zucker 大鼠负能量平衡的重要因素。 (C) 1998 爱思唯尔科学公司。
Intracerebroventricular (ICV) administration of glucagon-like peptide-1-(7-37) amide (GLP-1) has been shown to modulate food and water intake. The present studies further characterize the effects of ICV GLP-1 in the regulation of energy balance in lean and obese animals. In both obese and lean Zucker rats, a single ICV infusion of GLP-1 (1-30 mu g) resulted in a dose-dependent reduction of food intake and decrease in respiratory quotient relative to the saline control during the first 2 h of the nocturnal cycle. In obese Zucker rats, the food intake was reduced by 73 +/- 11% of the control at the 30 mu g dose, whereas a modest 45 +/- 18% reduction was observed in lean rats. Despite the large reduction in food intake seen with GLP-1, there was no compensatory decrease in nocturnal oxygen consumption in the obese Zucker rats. Interestingly, low doses of GLP-1 (1 mu g) in lean Zucker rats, which had minimal effects on food intake, caused a 19 +/- 7% increase in O-2 consumption during the first 2 h of the nocturnal cycle. These data suggest that central GLP-1 may be an important factor controlling negative energy balance in both the lean and obese Zucker rats. (C) 1998 Elsevier Science Inc.