The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation
The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation
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DOI：
10.1016/j.bbrc.2007.12.114
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发表时间：
2008-04-25
影响因子：
3.1
通讯作者：
Kobayashi, Tomoyoshi
中科院分区：
文献类型：
--
作者：
Solaro, R. John;Rosevear, Paul;Kobayashi, Tomoyoshi
我们回顾了心肌肌钙蛋白I在调节和调制心脏功能中的多种重要功能的证据和当前观点的发展。我们的重点是独特的结构功能关系的心肌肌钙蛋白I亚型，特别是含有磷酸化位点的区域。这些数据表明，通过磷酸化修饰特定区域的心肌肌钙蛋白I可以促进或降低心肌收缩力。因此，这些磷酸化的稳态平衡是控制心脏功能的一个重要方面。一个新的概念是，稳态机制可能涉及心肌肌钙蛋白I的分子内相互作用的修改。(c)2007年爱思唯尔公司All rights reserved.
We review development of evidence and current perceptions of the multiple and significant functions of cardiac troponin I in regulation and modulation of cardiac function. Our emphasis is on the unique structure function relations of the cardiac isoform of troponin I, especially regions containing sites of phosphorylation. The data indicate that modifications of specific regions cardiac troponin I by phosphorylations either promote or reduce cardiac contractility. Thus, a homeostatic balance in these phosphorylations is an important aspect of control of cardiac function. A new concept is the idea that the homeostatic mechanisms may involve modifications of intramolecular interactions in cardiac troponin I. (c) 2007 Elsevier Inc. All rights reserved.