Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia
Clinical biochemical parameters associated with the exposure to multiple environmental metals in residents from Kabwe, Zambia
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DOI：
10.1016/j.chemosphere.2020.127788
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发表时间：
2021-01-01
期刊：
影响因子：
8.8
通讯作者：
Ishizuka, Mayumi
中科院分区：
文献类型：
--
作者：
Nakata, Hokuto;Nakayama, Shouta M. M.;Ishizuka, Mayumi
铅（Pb）会干扰人体的各种功能。虽然有报告称赞比亚卡布韦居民血液中铅（Pb-B）含量较高，但其他金属的积累模式仍不清楚。该研究旨在确定来自Kabwe的504个代表性样本的Pb-B，血镉（Cd-B）和锌（Zn-B）值，以及潜在的相关不良健康影响。铅-硼含量在0.79至154.75微克/分升之间，在矿区附近地区普遍增加。在两个地区（0.37 +/- 0.26和0.32 +/- 0.30 μ g/L）观察到Cd-B的显著升高，其中两个地区记录了最高的平均Pb-B水平。相比之下，Zn-B值在面积方面没有很大差异。在大约20-50%的研究成人参与者中，与肝和肾功能相关的一些血液生化参数超出正常范围。δ-氨基乙酰丙酸脱氢酶（δ-ALAD）活性在Pb和Cd污染的两个地区均受到显著抑制。在金属水平和临床参数之间观察到显著的负相关性，例如，所有年龄组的Pb-B和Δ-ALAD之间以及所有年龄组（0-4岁除外）的Cd-B和估计肾小球滤过率之间的关系。矿区附近地区Cd-B相对于其他地区的升高表明Cd和/或Pb和Cd的交互作用可能对健康产生不利影响。金属水平与临床参数的显着关联也表明了金属暴露对造血系统，肝脏和肾脏系统的影响。(C)2020爱思唯尔有限公司保留所有权利。
Lead (Pb) interferes with various bodily functions. Although high blood Pb (Pb-B) levels in residents from Kabwe, Zambia have been reported, the accumulation pattern of other metals remains unknown. The study was designed to determine the Pb-B, blood cadmium (Cd-B), and zinc (Zn-B) values of 504 representative samples from Kabwe, as well as the potential associated adverse health effects. The Pb-B level ranged from 0.79 to 154.75 mu g/dL and generally increased in areas near the mine. A significant elevation of Cd-B was observed in two areas (0.37 +/- 0.26 and 0.32 +/- 0.30 mu g/L) where the two highest mean Pb-B levels were recorded. By contrast, the Zn-B values did not differ greatly with respect to area. Some blood biochemical parameters relating to hepatic and renal functions were out of the normal range in approximately 20-50% of studied adult participants. The delta-aminolevulinic acid dehydratase (delta -ALAD) activity was significantly inhibited in the two areas contaminated by Pb and Cd. A significant negative relationship was observed between metal levels and clinical parameters, e.g., between Pb-B and delta -ALAD for all the age categories and between Cd-B and the estimated glomerular filtration rate for all the age categories except 0-4 years. The elevated Cd-B in areas near the mine relative to the other areas suggested the potential adverse health effects of Cd and/or the interaction of Pb and Cd. A significant association of metal levels with clinical parameters also indicated the effects of metal exposure on hematopoietic, hepatic, and renal systems. (C) 2020 Elsevier Ltd. All rights reserved.