Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Aβ immunization
Potential treatment opportunities for Alzheimer's disease through inhibition of secretases and Aβ immunization
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DOI：
10.1385/jmn:17:2:259
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发表时间：
2001-10-01
影响因子：
3.1
通讯作者：
Seubert, P
中科院分区：
文献类型：
--
作者：
Schenk, D;Games, D;Seubert, P
在过去的十年里，对阿尔茨海默氏症的研究追求了许多机会。值得注意的是各种方法中与“淀粉样蛋白假说”有关的努力。这一假说认为，β-淀粉样肽导致了与疾病相关的广泛的神经病理和临床衰退。这一领域的广泛研究表明，β淀粉样肽是由被称为分泌酶的蛋白酶产生的，而且已经表明，分泌酶功能的阻断会减少β淀粉样肽的生成量。通过增加清除机制来减少β淀粉样蛋白的另一种方法是用多肽本身免疫并诱导抗体反应。然后，特定激发的抗体结合到大脑中并刺激肽从大脑中清除。这些发现刺激了几种方法来开发治疗阿尔茨海默病的新治疗策略，这些策略要么即将进入临床，要么已经进入临床。
Research over the past ten years on Alzheimer's disease has pursued many opportunities. Notable amongst the various approaches are efforts related to the "amyloid hypothesis." This hypothesis posits that the beta amyloid pepticle causes the extensive neuropathology and clinical decline associated with the disease. Extensive research in this area has shown that the beta amyloid peptide is produced by proteases termed "secretases" and it has been shown that blockade of secretase functions reduce the amount of beta amyloid peptide produced. An additional approach to reduce beta amyloid, through an increase in clearance mechanisms, is to immunize with the peptide itself and induce an antibody response. The specifically elicited antibodies then bind to and stimulate clearance of the pepticle from the brain. These findings have stimulated several approaches to develop novel therapeutic strategies to treat Alzheimer's disease that either are about or have entered the clinic.