A Comparison of Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential.
A Comparison of Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential.
复制标题
比较交替的极性和正向掩盖伪像还原方法，以解决电诱发的复合动作电位。
DOI：
10.1097/aud.0000000000000288
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发表时间：
2016-07
期刊：
影响因子：
3.7
通讯作者：
Goehring JL
中科院分区：
文献类型：
--
作者：
Baudhuin JL;Hughes ML;Goehring JL
人工耳蜗制造商利用不同的伪影减少方法来测量临床软件中的电诱发复合动作电位（ECAP）。两种商业上可用的伪影减少技术包括前向掩蔽（FwdMsk）和交替极性（AltPol）。AltPol假设对相反极性的反应是相等的，这可能是有问题的。另一方面，如果掩蔽器不能有效地使所有神经元进入不应状态，则FwdMsk可以产生不准确的波形。本研究的目的是比较ECAP阈值，振幅和振幅增长函数（AGF）的斜率使用FwdMsk和AltPol，以确定这两种方法是否产生类似的结果。采用FwdMsk和AltPol两种方法，从20名Cochiar Ltd.受体的24只耳朵的三个电极区域（基底、中间和顶端）获得ECAP AGF。AltPol波形无法解析使用旧一代芯片的器械接受者（CI 24 R（CS）; N=6）。在CI 24 RE和CI 512代设备中比较FwdMsk和AltPol的结果显示，两种方法之间的阈值、AGF斜率和振幅存在显著差异。与AltPol相比，FwdMsk导致较低的视觉检测阈值（p < 0.001）、较浅的斜率（p = 0.004）和较大的振幅（p = 0.03）。这项研究的结果是一致的，最近的研究结果表明，人类CI受体的极性之间的ECAP振幅和潜伏期的差异。当平均时，这些差异可能导致AltPol的ECAP响应降低。下一步将是分离伪影减少方法和刺激极性的影响，以确定各自的相对影响。
Cochlear-implant manufacturers utilize different artifact-reduction methods to measure electrically evoked compound action potentials (ECAPs) in the clinical software. Two commercially available artifact-reduction techniques include forward masking (FwdMsk) and alternating polarity (AltPol). AltPol assumes that responses to the opposing polarities are equal, which is likely problematic. On the other hand, FwdMsk can yield inaccurate waveforms if the masker does not effectively render all neurons into a refractory state. The goal of this study was to compare ECAP thresholds, amplitudes, and slopes of the amplitude growth functions (AGFs) using FwdMsk and AltPol to determine whether the two methods yield similar results. ECAP AGFs were obtained from three electrode regions (basal, middle, and apical) across 24 ears in 20 Cochlear Ltd. recipients using both FwdMsk and AltPol methods. AltPol waveforms could not be resolved for recipients of devices with the older-generation chip (CI24R(CS); N=6). Results comparing FwdMsk and AltPol in the CI24RE- and CI512-generation devices showed significant differences in threshold, AGF slope, and amplitude between methods. FwdMsk resulted in lower visual-detection thresholds (p < 0.001), shallower slopes (p = 0.004), and larger amplitudes (p = 0.03) compared with AltPol. Results from this study are consistent with recent findings showing differences in ECAP amplitude and latency between polarities for human CI recipients. When averaged, these differences likely result in a reduced ECAP response with AltPol. The next step will be to separate the effects of artifact-reduction method and stimulus polarity to determine the relative effects of each.