Variation in gut microbial contribution of essential amino acids to host protein metabolism in a wild small mammal community
Variation in gut microbial contribution of essential amino acids to host protein metabolism in a wild small mammal community
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DOI：
10.1111/ele.14246
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发表时间：
2023-06-08
期刊：
影响因子：
8.8
通讯作者：
Newsome，Seth D.
中科院分区：
文献类型：
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作者：
Besser，Alexi C.;Manlick，Philip J.;Newsome，Seth D.
食草动物是动物的主要摄食策略，但食草动物通常是蛋白质有限的。假设肠道微生物组通过提供必需的大分子来帮助维持宿主蛋白质平衡，但这从未在野生消费者中进行过测试。利用氨基酸碳（δ 13 C）和氮（δ 15 N）同位素分析，我们估计了肠道微生物合成的必需氨基酸（AAESS）对代表草食性、杂食性和食虫性功能群的5种共存荒漠啮齿动物的贡献比例。我们发现，草食性啮齿动物占据较低的营养位置（Dipodomysspp.）通过肠道微生物途径获得的AAESS40%-50%，而营养级较高的杂食动物Peromyscusspp.食虫动物（沙鼠）的大部分AAESS（~58%）来自植物能量通道，但仍有~20%来自肠道微生物。这些发现经验性地证明了肠道微生物在野生动物的宿主蛋白质代谢中起着关键的功能作用。
Herbivory is a dominant feeding strategy among animals, yet herbivores are often protein limited. The gut microbiome is hypothesized to help maintain host protein balance by provisioning essential macromolecules, but this has never been tested in wild consumers. Using amino acid carbon (δ13C) and nitrogen (δ15N) isotope analysis, we estimated the proportional contributions of essential amino acids (AAESS) synthesized by gut microbes to five co‐occurring desert rodents representing herbivorous, omnivorous and insectivorous functional groups. We found that herbivorous rodents occupying lower trophic positions (Dipodomysspp.) routed a substantial proportion (~40%–50%) of their AAESSfrom gut microbes, while higher trophic level omnivores (Peromyscusspp.) and insectivores (Onychomys arenicola) obtained most of their AAESS(~58%) from plant‐based energy channels but still received ~20% of their AAESSfrom gut microbes. These findings empirically demonstrate that gut microbes play a key functional role in host protein metabolism in wild animals.