Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation
Microparticle-associated tissue factor activity in dogs with disseminated intravascular coagulation
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DOI：
10.1292/jvms.19-0553
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发表时间：
2019-12
期刊：
影响因子：
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通讯作者：
Kosuke Kobayashi;K. Baba;M. Igase;T. Miyama;S. Kambayashi;M. Okuda
中科院分区：
文献类型：
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作者：
Kosuke Kobayashi;K. Baba;M. Igase;T. Miyama;S. Kambayashi;M. Okuda
血浆中微粒子（MP）相关组织因子（TF）活性可能在人弥散性血管内凝血（DIC）中起作用。本研究的目的是比较非DIC和DIC组之间的MP-TF活性。入选10只临床健康比格犬和26只患病犬。DIC组MP-TF活性升高的犬比例显著高于非DIC组（P = 0.014）。DIC组MP-TF活性显著高于非DIC组（P = 0.021）。MP-TF活性与血浆D-二聚体浓度呈正相关（r = 0.42，P = 0.034）。此外，MP-TF活性在一些DIC犬中随着恢复时间的推移而降低。更大规模的前瞻性研究是必要的，以评估其作为DIC诊断和预后生物标志物的价值。
Microparticle (MP)-associated tissue factor (TF) activity in plasma might play a role in human disseminated intravascular coagulation (DIC). The aim of this study was to compare MP-TF activity between non-DIC and DIC groups. Ten clinically healthy beagles and 26 diseased dogs were enrolled. The proportion of dogs with increased MP-TF activity was significantly higher in the DIC group than the non-DIC group (P=0.014). MP-TF activity in the DIC group was significantly higher than the non-DIC group (P=0.021). MP-TF activity positively correlated with plasma D-dimer concentration (r=0.42, P=0.034). Moreover, MP-TF activity was decreased by the time of recovery in some dogs with DIC. Larger prospective studies are warranted to assess its value as a diagnostic and prognostic biomarker in DIC.