Hydroxyurea dermopathy: A unique lichenoid eruption complicating long-term therapy with hydroxyurea
Hydroxyurea dermopathy: A unique lichenoid eruption complicating long-term therapy with hydroxyurea
复制标题
DOI：
10.1016/s0190-9622(97)70276-7
复制
发表时间：
1997-02-01
影响因子：
13.8
通讯作者：
Pittelkow, MR
中科院分区：
文献类型：
--
作者：
Daoud, MS;Gibson, LE;Pittelkow, MR
背景：羟基脲通常是一种耐受性良好的抗肿瘤药物。目的：我们的目的是描述长期接受羟基脲治疗的患者的独特临床和组织学上的皮疹。方法：对6例羟基脲性皮肤病的临床、组织学和免疫病理特征进行分析。结果：三女三男。平均年龄为61岁。羟基脲平均使用5年。手背和指背的地衣样丘疹、毛细血管扩张和千疮性病变是最常见的发现。界面皮炎、局灶性地衣样反应伴表皮萎缩和Civatte小体是最常见的组织学表现。内皮细胞肿胀也被发现。多偶联的胞质染色是最常见的免疫病理发现。4例患者停药后症状明显好转。结论：长期给药羟基脲有明显的皮肤反应。停止治疗对于治愈或改善是必要的。我们认为这次爆发是水疱性皮肤病。
Background: Hydroxyurea is usually a well, tolerated antitumor agent.Objective: Our purpose was to describe a distinct clinical and histologic eruption in patients receiving long-term hydroxyurea therapy.Methods: The clinical, histologic, and immunopathologic features of six patients with hydroxyurea dermopathy are described.Results: Three women and three men were identified. The average age was 61 years. Hydroxyurea had been used for an average of 5 years. Lichenoid papules, telangiectasia, and poikilodermatous lesions on the dorsal hands and digits were the most common findings. Interface dermatitis, focal lichenoid reaction with epidermal atrophy, and Civatte bodies were the most common histologic findings. Endothelial swelling also was noted. Cytoid staining with multiple conjugates was the most common immunopathologic finding. Four patients showed significant improvement after discontinuation of hydroxyurea.Conclusion: A distinct cutaneous reaction to long-term administration of hydroxyurea has been characterized. Cessation of treatment is necessary for healing or improvement. We have designated this eruption hydroxurea dermopathy.