The relationship between cognitive change and physical health and behavioural outcomes in a Ugandan cohort of adults living with HIV - a longitudinal study.
The relationship between cognitive change and physical health and behavioural outcomes in a Ugandan cohort of adults living with HIV - a longitudinal study.
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乌干达成人艾滋病毒感染者队列中认知变化与身体健康和行为结果之间的关系——一项纵向研究。
DOI：
10.1080/09540121.2018.1545987
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发表时间：
2019
期刊：
影响因子：
1.7
通讯作者：
Kinyanda,E
中科院分区：
文献类型：
--
作者：
Spies,G;Denckla,CA;Mall,S;Levin,J;Seedat,S;Nakasujja,N;Kinyanda,E
我们调查了1126名乌干达成年艾滋病毒感染者在基线和12个月后的认知功能、身体健康和行为结果（艾滋病毒疾病进展、寻求健康的行为、对艾滋病毒药物的依从性和危险性行为）的变化。总体而言，认知功能从基线到随访有所改善，但步态速度除外，其在随访时比基线慢。有改善的身体健康和行为结果的后续行动，与更大的改善个体之间的ART相比，那些没有对ART的步态速度随时间的变化显着预测危险的性行为在后续行动。这是第一项调查乌干达成年艾滋病毒感染者认知功能与健康结果之间纵向关系的研究，并深入了解艾滋病毒感染者认知功能与负面临床和行为健康结果之间的可能联系。
We investigated changes in cognitive function and physical health and behavioural outcomes (HIV disease progression, health-seeking behaviour, adherence to HIV medications and risky sexual behaviour) at baseline and 12 months later among 1126 Ugandan adults living with HIV. Overall, cognitive function improved from baseline to follow-up, except for gait speed, which was slower at follow-up compared to baseline. There were improvements in physical health and behavioural outcomes by follow-up, with greater improvements among individuals on ART compared to those not on ART. Change in gait speed over time significantly predicted risky sexual behaviours at follow-up. This is the first study to investigate the longitudinal relationships between cognitive function and health outcomes among Ugandan adults living with HIV and provide insights into the possible links between cognitive function and negative clinical and behavioural health outcomes in people living with HIV.