The three sorCS genes are differentially expressed and regulated by synaptic activity
The three sorCS genes are differentially expressed and regulated by synaptic activity
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DOI：
10.1046/j.1471-4159.2004.02286.x
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发表时间：
2004-03-01
影响因子：
4.7
通讯作者：
Hermans-Borgmeyer, I
中科院分区：
文献类型：
--
作者：
Hermey, G;Plath, N;Hermans-Borgmeyer, I
我们分离出了小鼠 sorCS3 基因，它是含有 Vps10p 结构域的受体家族的新成员。该家族的受体促进快速内吞作用，并被认为参与细胞内分选。 SorCS3 和高度同源的 sorCS1 和 sorCS2 基因在发育中和成熟的中枢神经系统中以组合的、大部分不重叠的模式表达。在开发过程中，其转录本的分布和丰富度受到监管。此外，它们的表达受到成年小鼠海马神经元活动的不同影响。尽管红藻氨酸诱导的癫痫发作对 sorCS2 mRNA 水平没有影响，但它们显着增加了 sorCS1 和 sorCS3 的表达。 sorCS1 表达的活性依赖性诱导需要从头合成蛋白质，而 sorCS3 则不需要。我们的结果表明，三个 sorCS 基因在发育和成熟的中枢神经系统中具有不同但部分重叠的功能。
We have isolated the murine sorCS3 gene, a new member of the family of receptors containing a Vps10p-domain. Receptors of this family facilitate rapid endocytosis and are thought to be involved in intracellular sorting. SorCS3 and the highly homologous sorCS1 and sorCS2 genes were expressed in a combinatorial, mostly non-overlapping pattern in both the developing and mature central nervous system. During development, distribution and abundancy of their transcripts was regulated. Moreover, their expression was differentially influenced by neuronal activity in the hippocampus of adult mice. Although kainic acid-induced seizures had no effect on sorCS2 mRNA levels, they dramatically increased the expression of sorCS1 and sorCS3. The activity-dependent induction of sorCS1 expression required de novo protein synthesis, whereas that of sorCS3 did not. Our results imply that the three sorCS genes have diverse, but partly overlapping functions in the developing and mature central nervous system.