Predicted Coronary Heart Disease Risk Decreases in Obese Patients After Laparoscopic Sleeve Gastrectomy
Predicted Coronary Heart Disease Risk Decreases in Obese Patients After Laparoscopic Sleeve Gastrectomy
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DOI：
10.1007/s00268-017-4416-6
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发表时间：
2018-07
影响因子：
2.6
通讯作者：
Cheng-Chiao Huang;Weu Wang;R. Chen;P. Wei;C. Tzao;Ping-Ling Chen
中科院分区：
文献类型：
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作者：
Cheng-Chiao Huang;Weu Wang;R. Chen;P. Wei;C. Tzao;Ping-Ling Chen
目的评估病态肥胖患者腹腔镜袖状胃切除术（LSG）术后6个月和12个月的Frachial风险评分降低情况。材料和方法回顾性研究了2007年6月至2014年6月在台北医学大学附属医院接受LSG的870例病态肥胖患者术前、术后6个月和12个月的Frachial风险评分。结果术前体重指数（BMI）分别为43.3 ± 6.9、39.2 ± 6.0 kg/m2，术后体重指数分别为32.9 ± 6.7、31.0 ± 5.2 kg/m2和30.4 ± 5.6、28.2 ± 4.7 kg/m2;术后6个月和12个月时，P< 0.0001。在LSG后6个月和12个月，血脂谱有明显改善，糖尿病、全身性高血压和吸烟的患病率显著下降。男性和女性的脆性风险评分分别从术前的3.2 ± 5.7、6.1 ± 5.7降至1.4 ± 5.9、3.3 ± 5.9和0.1 ± 6.2、2.8 ± 6.1，术后6和12个月结论腹腔镜袖状胃切除术不仅能有效减少肥胖及其相关并发症的发生，而且能降低远期冠状动脉事件的发生率。强烈建议对高危人群进行早期干预。
PurposeTo assess the reduction of 6 and 12 months postoperatively of Framingham risk score in morbidly obese patients with laparoscopic sleeve gastrectomy (LSG).Material and methodsIn total, 870 morbid obesity patients received LSG in Taipei Medical University Hospital from June 2007 to June 2014 were retrospectively studied preoperatively, 6 and 12 months after surgery. The coronary heart disease risk was calculated using Framingham risk score.ResultsThe body mass index in men and women decreased from 43.3 ± 6.9, 39.2 ± 6.0 kg/m2preoperatively to 32.9 ± 6.7, 31.0 ± 5.2 kg/m2and to 30.4 ± 5.6 , 28.2 ± 4.7 kg/m2, respectively, at 6 and 12 months after surgery (P< 0.0001). At 6 and 12 months after LSG, there was a marked improvement on lipid profile as well as a significant decline in the prevalence of diabetes mellitus, systemic hypertension, and smoking. The Framingham risk score in men and women reduced from 3.2 ± 5.7, 6.1 ± 5.7 preoperatively to 1.4 ± 5.9, 3.3 ± 5.9 and 0.1 ± 6.2, 2.8 ± 6.1, respectively, at 6 and 12 months after surgery (P< 0.0001).ConclusionsLaparoscopic sleeve gastrectomy is efficient not only in the reduction of obesity and its related comorbidities but also in decreasing the long-term coronary event risk. Early intervention for the high-risk group is strongly recommended.