Pitfalls in cefepime titration from human plasma: Plasma- and temperature-related drug degradation in vitro
Pitfalls in cefepime titration from human plasma: Plasma- and temperature-related drug degradation in vitro
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DOI：
10.1128/aac.46.11.3654-3656.2002
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发表时间：
2002-11-01
影响因子：
4.9
通讯作者：
Moreillon, P
中科院分区：
文献类型：
--
作者：
Bugnon, D;Giannoni, E;Moreillon, P
在开发血浆中头孢吡肟的高压液相色谱测定法时，我们观察到在20和37 ℃下有显著的药物降解，但在4 ℃下没有。这种血浆相关降解在蛋白质去除后持续存在。因此，在进行头孢吡肟体外和体内药代动力学和药效学研究时，应谨慎使用头孢吡肟测定法。
While developing a high-pressure liquid chromatography assay for cefepime in plasma, we observed significant drug degradation at 20 and 37 degreesC but not at 4 degreesC. This plasma-related degradation persisted after protein removal. This warrants caution regarding cefepime assays for pharmacokinetic and pharmacodynamic studies of cefepime in vitro and in vivo.