Aspects of the general biology of adenosine A2A signaling
Aspects of the general biology of adenosine A2A signaling
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DOI：
10.1016/j.pneurobio.2007.07.005
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发表时间：
2007-12-01
影响因子：
6.7
通讯作者：
Sitkovsky, Michail
中科院分区：
文献类型：
--
作者：
Fredholm, Bertil B.;Chern, Yijuang;Sitkovsky, Michail
我们目前希望找到更好的方法来治疗帕金森氏症或阻止其发展，依赖于对大脑中腺苷A（2A）受体的研究。然而，任何靶向中枢受体的药物也可能影响其他部位的受体。此外，腺苷受体生物学的几个基本方面必须考虑在内。由于这些原因，在波士顿举行的“帕金森病和其他中枢神经系统疾病的靶向腺苷A（2A）受体”会议包括了腺苷A（2A）受体信号传导的一般生物学方面的选择。第一章总结了会议这一部分的一些报告。对于读者来说，这些不同的部分并不能形成一个完整的整体，但它们确实表明了组织者认为可能阐明关于腺苷A（2A）受体作用的剩余问题的领域。本部分会议的撰稿人总结了以下一些关键问题。(C) 2007 Elsevier Ltd.版权所有。
Many of our current hopes of finding better ways to treat Parkinson's disease or to stop its progression rely on studies of adenosine A(2A) receptors in the brain. Yet any drug targeting central receptors will also potentially affect receptors in other sites. Furthermore, several fundamental aspects of adenosine receptor biology must be taken into account. For these reasons the "Targeting adenosine A(2A) receptors in Parkinson's disease and other CNS disorders" meeting in Boston included selected aspects of the general biology of adenosine A(2A) receptor signaling. Some of the presentations from this part of the meeting are summarized in this first chapter. As will be apparent to the reader, these different parts do not form an integrated whole, but they do indicate areas the organizers felt might illuminate remaining questions regarding the roles of adenosine A(2A) receptors. The contributors to this part of the meeting have summarized some of the key questions below. (C) 2007 Elsevier Ltd. All rights reserved.