The Association between the Dietary Inflammatory Index and Thyroid Function in U.S. Adult Males.
The Association between the Dietary Inflammatory Index and Thyroid Function in U.S. Adult Males.
复制标题
美国成年男性饮食炎症指数与甲状腺功能之间的关联
作者：
Liu N;Ma F;Feng Y;Ma X
甲状腺功能与炎症有着密切的联系。然而，目前尚不清楚饮食炎症潜力是否与甲状腺功能相关。我们的目的是评估他们之间的关系使用的数据从国家健康和营养调查（NHANES）。本研究是一项横断面研究，采用加权多变量线性回归、亚组分析和相互作用项。甲状腺功能测定采用8项指标，包括总T4、游离T3、Tg、TgAb、TPOAb和TSH。共入组2346例年龄≥20岁的男性受试者，平均年龄为50.74 ± 17.68岁。参与者的平均DII评分为-0.46 ± 1.73，范围为-4.12至4.41，平均总甲状腺素（T4）为7.61 ± 1.51 μg/dL。我们发现DII和总T4之间呈正相关（β = 0.07; p = 0.0044）。使用亚组分析，这种关联在碘缺乏组和肥胖组中都变得更强（碘缺乏组：β = 0.15，p < 0.0001;肥胖组：β = 0.14，p < 0.0001）。总之，坚持更促炎饮食的男性似乎有更高的总T4水平。然而，这些激素变化仍在正常临床范围内，仍需要更多精心设计的研究来验证DII和甲状腺功能之间的因果关系。
Thyroid function has a close link with inflammation. However, it is still unknown whether the dietary inflammatory potential is associated with thyroid function. We aimed to assess the relationship among them using the data from the National Health and Nutrition Examination Survey (NHANES). This study was a cross-sectional study, where weighted multivariable linear regression, subgroup analyses, and interaction terms were employed. Thyroid function was assessed by eight indexes, including total and free T4 and T3, Tg, TgAb, TPOAb, and TSH. A total of 2346 male participants aged ≥20 years with an average age of 50.74 ± 17.68 years were enrolled. The mean DII score among participants was −0.46 ± 1.73, ranging from −4.12 to 4.41, and mean total thyroxine (T4) was 7.61 ± 1.51 μg/dL. We found a positive association between DII and total T4 (β = 0.07; p = 0.0044). Using subgroup analysis, this association became stronger in both the iodine-deficient and obese group (iodine-deficient group: β = 0.15, p < 0.0001; obese group: β = 0.14, p < 0.0001). In conclusion, men adhering to a more pro-inflammatory diet appeared to have higher total T4 levels. However, these hormone variations were still within the normal clinical range and more well-designed studies are still needed to validate the causal relationship between DII and thyroid function.