Directing T cell differentiation and function with small molecule inhibitors
Directing T cell differentiation and function with small molecule inhibitors
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DOI：
10.4161/cc.6444
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发表时间：
2008-08-01
期刊：
影响因子：
4.3
通讯作者：
Merkenschlager, Matthias
中科院分区：
文献类型：
--
作者：
Bruno, Ludovica;Merkenschlager, Matthias
表达特征性转录因子Foxp3的调节性T（Treg）细胞可防止自身免疫和免疫病理。近期研究表明，由磷脂酰肌醇3激酶（PI3K）、Akt和哺乳动物雷帕霉素靶蛋白（mTOR）组成的信号网络调节CD4 T细胞中Foxp3的从头表达。除了CD4 T细胞分化外，PI3K/Akt/mTOR信号传导还控制T细胞迁移。在此我们综述新的数据，考虑其进化背景，并讨论其对免疫疗法的潜在影响。
Regulatory T (Treg) cells that express the signature transcription factor Foxp3 safeguard against autoimmunity and immune pathology. Recent studies show that a signaling network with the components phosphatidyl inositol 3 kinase (PI3K), Akt, and the mammalian target of rapamycin (mTOR) regulates the de novo expression of Foxp3 in CD4 T cells. In addition to CD4 T cell differentiation, PI3K/Akt/mTOR signaling also controls T cell migration. Here we review the new data, consider their evolutionary context and discuss their potential implications for immunotherapy.