Scaffold development using selective laser sintering of polyetheretherketone-hydroxyapatite biocomposite blends
Scaffold development using selective laser sintering of polyetheretherketone-hydroxyapatite biocomposite blends
复制标题
DOI：
10.1016/s0142-9612(03)00131-5
复制
发表时间：
2003-08-01
期刊：
影响因子：
14
通讯作者：
Cha, SW
中科院分区：
文献类型：
--
作者：
Tan, KH;Chua, CK;Cha, SW
组织工程学（TE）。临时三维支架对于引导细胞增殖和维持再生生物组织或器官中的天然表型是必需的。为了制造支架，快速成型（RP）技术正在成为首选的制造技术，因为它们能够克服传统的基于手动的制造工艺所遇到的许多限制。本研究主要探讨无溶剂聚合物多孔支架与复合材料多孔支架的快速成型。在商业化的选择性激光烧结（SLS）快速成型系统上对聚醚醚酮（PEEK）和羟基磷灰石（HA）等生物材料进行了实验加工。SLS技术非常有利，因为它通过调整SLS工艺参数为用户提供了对所创建支架微观结构的良好控制。对物理混合的PEEK/HA粉末共混物的不同重量百分比（wt%）组合物进行烧结以评估其对SLS加工的适用性。使用电子显微镜进行支架的微观结构评估。结果确定了SLS制造的TE支架的潜力。(C)2003爱思唯尔科技有限公司版权所有。
In tissue engineering (TE). temporary three-dimensional scaffolds are essential to guide cell proliferation and to maintain native phenotypes in regenerating biologic tissues or organs. To create the scaffolds, rapid prototyping (RP) techniques are emerging as fabrication techniques of choice as they are capable of overcoming many of the limitations encountered with conventional manual-based fabrication processes. In this research, RP fabrication of solvent free porous polymeric and composite scaffolds was investigated. Biomaterials Such as polyetheretherketone (PEEK) and hydroxyapatite (HA) were experimentally processed on a commercial selective laser sintering (SLS) RP system. The SLS technique is highly advantageous as it provides good user control over the microstructures of created scaffolds by adjusting the SLS process parameters. Different weight percentage (wt%) compositions of physically mixed PEEK/HA powder blends were sintered to assess their suitability for SLS processing. Microstructural assessments of the scaffolds were conducted using electron microscopy. The results ascertained the potential of SLS-fabricated TE scaffolds. (C) 2003 Elsevier Science Ltd. All rights reserved.