Impact of Peripheral Artery Disease on Prognosis in Hospitalized Heart Failure Patients
Impact of Peripheral Artery Disease on Prognosis in Hospitalized Heart Failure Patients
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DOI：
10.1253/circj.cj-14-1280
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发表时间：
2015-04-01
影响因子：
3.3
通讯作者：
Takeishi, Yasuchika
中科院分区：
文献类型：
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作者：
Nakamura, Yuichi;Kunii, Hiroyuki;Takeishi, Yasuchika
背景：外周动脉疾病（PAD）对心力衰竭（HF）预后的影响尚不清楚。方法与结果：将388例连续失代偿期HF患者根据有无PAD分为伴有PAD的HF （PAD组，n=101, 26.0%）和无PAD的HF（非PAD组，n=287, 74.0%）两组。我们比较了两组患者的临床特征、超声心动图参数、心肺运动试验结果、实验室检查结果以及心脏、非心脏和全因死亡率。与非PAD组相比，PAD组(1)冠状动脉疾病（40.6%比27.5%，P=0.011）和脑血管疾病（34.7%比18.2%，P=0.001）的患病率更高；(2)肿瘤坏死因子α （1.82 vs. 1.49 pg/ml， P=0.023）、c反应蛋白（0.32 vs. 0.19 mg/dl， P=0.045）、肌钙蛋白T （0.039 vs. 0.021 ng/ml， P=0.019）升高；(3) LVEF降低(42.4 vs. 48.5%， P
Background: The impact of peripheral artery disease (PAD) on heart failure (HF) prognosis remains unclear.Methods and Results: A total of 388 consecutive decompensated HF patients were divided into 2 groups based on the presence of PAD: HF with PAD (PAD group, n=101, 26.0%) and HF without PAD (non-PAD group, n=287, 74.0%). We compared clinical features, echocardiographic parameters, cardiopulmonary exercise testing results, laboratory findings, as well as cardiac, non-cardiac, and all-cause mortality between the 2 groups. The PAD group, as compared with the non-PAD group, had (1) higher prevalence of coronary artery disease (40.6 vs. 27.5%, P=0.011) and cerebrovascular disease (34.7 vs. 18.2%, P=0.001); (2) higher tumor necrosis factor-alpha (1.82 vs. 1.49 pg/ml, P=0.023), C-reactive protein (0.32 vs. 0.19 mg/dl, P=0.045), and troponin T (0.039 vs. 0.021 ng/ml, P=0.019); (3) lower LVEF (42.4 vs. 48.5%, P