Bisphenol A deteriorates egg quality through HDAC7 suppression.
Bisphenol A deteriorates egg quality through HDAC7 suppression.
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双酚 A 通过抑制 HDAC7 降低卵子质量
DOI：
10.18632/oncotarget.21308
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发表时间：
2017-11-03
期刊：
影响因子：
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通讯作者：
Gao Y
中科院分区：
文献类型：
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作者：
Liu B;Zhou S;Yang C;Chen P;Chen P;Xi D;Zhu H;Gao Y
双酚A（BPA）是一种人工合成的内分泌干扰物，广泛分布于环境中，可影响卵巢卵泡的健康，从而影响受精能力和妊娠率。然而，关于BPA如何破坏鸡蛋质量的潜在机制尚未完全揭示。在这项研究中，我们确定BPA处理的雌性小鼠与对照组相比，卵巢和卵子中的HDAC7表达降低。此外，BPA处理后H3K9和H4K16乙酰化的总体水平异常增加，并在HDAC7补偿后部分恢复。总的来说，我们的研究表明BPA通过HDAC7抑制使鸡蛋质量恶化。
Bisphenol A (BPA), a synthetic substance of endocrine disrupter, widely distributes in environment and can affect the health of ovarian follicles, thereby impacting the fertilization ability and pregnancy rate. However, the underlying mechanisms regarding how BPA disrupts the egg quality have not been fully revealed. In this study, we determine that BPA treated female mice display the decreasing HDAC7 expression in ovary and eggs compared to control. Moreover, the global levels of H3K9 and H4K16 acetylation abnormally increase after BPA treatment and recover partially upon HDAC7 compensation. Collectively, our study reveals that BPA deteriorates egg quality through HDAC7 suppression.