Macrophages set the bar for acute pain sensitivity.

Macrophages set the bar for acute pain sensitivity.
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巨噬细胞为急性疼痛敏感性设定了标准。

DOI:
10.1038/s41590-023-01438-9
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发表时间:
2023
期刊:
影响因子:
30.5
通讯作者:
Woolf,CliffordJ
Woolf,CliffordJ
中科院分区:
医学1区
文献类型:
--
作者:
Hakim,Sara;Woolf,CliffordJ

文献摘要

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一项对小鼠的偶然行为观察导致了巨噬细胞调节急性疼痛的发现。巨噬细胞衍生蛋白SNX25通过向皮肤感觉神经元传递紧张性NGF信号来设定急性疼痛的阈值。
A serendipitous behavioral observation in a mouse line led to the discovery that macrophages modulate acute pain. The macrophage-derived protein SNX25 sets the threshold for acute pain through tonic NGF signaling to cutaneous sensory neurons.