Shining a light on bacterial environmental cue integration and its relation to metabolism.
Shining a light on bacterial environmental cue integration and its relation to metabolism.
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揭示细菌环境线索整合及其与新陈代谢的关系。
DOI：
10.1111/mmi.15065
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发表时间：
2023
影响因子：
3.6
通讯作者：
Tan,Shumin
中科院分区：
文献类型：
--
作者：
Chen,Yue;Quirk,NataliaF;Tan,Shumin
一个细菌成功地在其宿主上定居的能力取决于它对当地环境的适当适应。环境线索在本质上是多种多样的，从离子到细菌产生的信号，以及也可以被细菌利用作为线索的宿主免疫反应。同时，细菌的新陈代谢必须与特定时间和地点的碳源和氮源相匹配。虽然细菌对给定环境线索的响应或其利用特定碳/氮源的能力的初始表征需要孤立地研究所讨论的信号，但实际感染造成了多个信号同时存在的情况。这种观点集中在未开发的潜力，发现和了解细菌如何整合他们的反应，多个并发的环境线索，并在阐明可能的内在协调细菌的环境反应与其代谢。
The ability of a bacterium to successfully colonize its host is dependent on proper adaptation to its local environment. Environmental cues are diverse in nature, ranging from ions to bacterial‐produced signals, and to host immune responses that can also be exploited by the bacteria as cues. Simultaneously, bacterial metabolism must be matched to the carbon and nitrogen sources available at a given time and location. While initial characterization of a bacterium's response to a given environmental cue or its ability to utilize a particular carbon/nitrogen source requires study of the signal in question in isolation, actual infection poses a situation where multiple signals are present concurrently. This perspective focuses on the untapped potential in uncovering and understanding how bacteria integrate their response to multiple concurrent environmental cues, and in elucidating the possible intrinsic coordination of bacterial environmental response with its metabolism.