Cobalt-Catalyzed Biaryl Couplings via C-F Bond Activation in the Absence of Phosphine or NHC Ligands
Cobalt-Catalyzed Biaryl Couplings via C-F Bond Activation in the Absence of Phosphine or NHC Ligands
复制标题
在没有膦或 NHC 配体的情况下通过 C-F 键活化实现钴催化联芳基偶联
DOI：
10.1021/acs.joc.6b02354
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发表时间：
2017
影响因子：
3.6
通讯作者：
Duan Xin-Fang
中科院分区：
文献类型：
--
作者：
Wei Juan;Liu Kun-Ming;Duan Xin-Fang
本文报道了一种在无膦或无NHC条件下，通过C-F断裂实现的具有高度通用性和选择性的Co催化联芳基偶联反应。在CoCl 2/DMPU催化下，包括未活化的氟代化合物以及具有敏感官能团的氟代化合物都可以与Ti（OEt）4介导的芳基格氏试剂高选择性地偶联.重要的是，还可以实现两种类型的氟（二氟化芳族化合物和两种不同的偶联配偶体）之间以及在C-Cl或C-Br键存在下的选择性C-F键活化偶联。
A highly general and selective Co-catalyzed biaryl coupling through C–F cleavage under phosphine or NHC-free conditions was described. A broad range of aryl fluorides including unactivated fluorides as well as those with sensitive functionalities could couple with various Ti(OEt)4-mediated aryl Grignard reagents with high selectivity under the catalysis of CoCl2/DMPU. Importantly, selective C–F bond activation couplings between two types of fluorines (difluorinated aromatics and on two different coupling partners) and in the presence of C–Cl or C–Br bonds could also be achieved.