Synthesis of PMMA Microparticles with a Narrow Size Distribution by Photoinitiated RAFT Dispersion Polymerization with a Macromonomer as the Stabilizer
Synthesis of PMMA Microparticles with a Narrow Size Distribution by Photoinitiated RAFT Dispersion Polymerization with a Macromonomer as the Stabilizer
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DOI：
10.1021/ma501432s
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发表时间：
2014-09
期刊：
影响因子：
5.5
通讯作者：
Jianbo Tan;Guangyao Zhao;Yijie Lu;Z. Zeng;M. Winnik
中科院分区：
文献类型：
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作者：
Jianbo Tan;Guangyao Zhao;Yijie Lu;Z. Zeng;M. Winnik
大分子单体可以作为单体如苯乙烯和甲基丙烯酸甲酯的分散聚合的高效和有效的稳定剂，但所获得的聚合物微粒的尺寸分布往往是宽的。我们对可用于免疫测定的功能性微珠感兴趣，其中尺寸分布必须非常窄。以甲基丙烯酸甲氧基聚乙二醇酯（Mn = 2000 g/mol，EO 45）为反应性空间稳定剂，在乙醇-水体系中进行了甲基丙烯酸甲酯（MMA）的RAFT光引发分散聚合。我们确定的反应条件下，可以获得PMMA微球的粒径（CVd）的变异系数小于3%。采用两步种子聚合法，在第二步中加入甲基丙烯酸（MAA）作为共聚单体，制备了羧基功能化的聚甲基丙烯酸甲酯微球。我们表明，以这种方式制备的功能微球是有效的基板的共价连接的蛋白质，如…
Macromonomers can serve as efficient and effective stabilizers for dispersion polymerization of monomers such as styrene and methyl methacrylate, but the size distributions of the polymer microparticles obtained tend to be broad. We are interested in functional microbeads which can be used for immunoassays, where the size distribution has to be very narrow. We report a photoinitiated RAFT dispersion polymerization of methyl methacrylate (MMA) in ethanol–water mixtures, with methoxy-poly(ethylene glycol) methacrylate (Mn = 2000 g/mol, EO45) as the reactive steric stabilizer. We identify reaction conditions where one can obtain PMMA microspheres with coefficient of variation in the particle diameter (CVd) less than 3%. Carboxy-functional PMMA microspheres were obtained by a two-stage (seeded) polymerization with methacrylic acid (MAA) added as a comonomer in the second stage. We show that the functional microspheres prepared in this way are effective substrates for the covalent attachment of proteins such a...