Widening the usefulness of epoxides and aziridines in synthesis
Widening the usefulness of epoxides and aziridines in synthesis
复制标题
扩大环氧化物和氮丙啶在合成中的用途
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Steven P Hughes
中科院分区：
文献类型：
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作者：
D. Hodgson;P. Humphreys;Steven P Hughes
末端环氧化物和叠氮醚与有机锂/二胺组合或锂酰胺的脱质子反应允许区域和立体选择性形成α-锂化物质。反应条件的明智选择允许这些物质作为亲核试剂、烯酸酯等价物、乙烯基阳离子等价物或羰基。
Abstract Deprotonation of terminal epoxides and aziridines with organolithium/diamine combinations or lithium amides allows the regio- and stereoselective formation of α-lithiated species. Judicious choice of reaction conditions allows these species to operate as nucleophiles, enolate equivalents, vinyl cation equivalents, or carbenes.