Sustained Inward Current and Pacemaker Activity of Mammalian Sinoatrial Node
Sustained Inward Current and Pacemaker Activity of Mammalian Sinoatrial Node
复制标题
哺乳动物窦房结的持续内向电流和起搏器活动
DOI：
10.1046/j.1540-8167.2002.00809.x
复制
发表时间：
2002
影响因子：
2.7
通讯作者：
M. Boyett
中科院分区：
文献类型：
--
作者：
Henggui Zhang;A. Holden;M. Boyett
窦房结持续内向电流。简介：在家兔、豚鼠和大鼠窦房结以及家兔房室结的起搏细胞中，已经描述了一种新的持续内向Na+电流ist，该电流对Ca2+拮抗剂敏感，并被β肾上腺素能刺激增强。虽然ist被认为是一种重要的起搏电流，但由于缺乏特异性阻断剂，这从未经过实验测试。在这项研究中，我们使用计算机模型来研究ist在窦房结细胞起搏活动中的作用。
Sustained Inward Current in the Sinoatrial Node. Introduction: A novel sustained inward Na+ current ist, which sensitive to Ca2+‐antagonists and potentiated by beta‐adrenergic stimulation, has been described in pacemaker cells of rabbit, guinea pig, and rat sinoatrial node, as well as rabbit AV node. Although ist has been suggested to be an important pacemaker current, this has never been tested experimentally because of the lack of a specific blocker. In this study, we address the role of ist in the pacemaker activity of the sinoatrial node cell using computer models.