Relationship of p53 and c-erbB-2 expression to histopathological features, Helicobacter pylori infection and prognosis in gastric cancer.
Relationship of p53 and c-erbB-2 expression to histopathological features, Helicobacter pylori infection and prognosis in gastric cancer.
复制标题
胃癌p53和c-erbB-2表达与组织病理学特征、幽门螺杆菌感染及预后的关系。
作者：
C. Shun;Ming;Lin Jt;Chen Sy;Hsiu‐Po Wang;Wen;Teh‐Hong Wang;S. Chuang
背景/目的
本文对p53和c-erbB-2的异常表达与胃癌生物学行为的关系进行了探讨。因此，p53和c-erbB-2的过度表达与胃癌的以下方面的关系：肿瘤组织病理学，幽门螺杆菌感染和预后进行了探讨。
材料和方法
p53和c-erbB-2的表达与组织病理学、H. 112例胃癌患者幽门螺杆菌感染与预后的关系
结果
p53蛋白阳性表达率为54.5%（61/112）。p53表达与性别、年龄、淋巴结转移、H.幽门螺杆菌感染或预后。p53蛋白在进展期胃癌、肠癌和贲门癌中的阳性表达率分别为60.7%、69.8%和76.5%，明显高于早期胃癌、弥漫型胃癌和非贲门癌，差异有显著性（P <0.01）。c-erbB-2阳性表达34例（30.3%），与性别、年龄、H. pylori感染和肿瘤位置。c-erbB-2染色阳性的肿瘤似乎更具侵袭性，因为淋巴结转移率较高（38.0% vs 17.1%，p < 0.05）、晚期（37.1% vs 4.3%，p < 0.01）和平均生存率较低（p < 0.01）。肠型肿瘤c-erbB-2阳性表达率为39.7%，明显高于弥漫型肿瘤18.4%（P < 0.01）。
结论
我们的研究结果表明，p53和c-erbB-2的免疫组化表达与一些组织病理学表型显着相关。c-erbB-2或p53的遗传改变可能不受H的影响。幽门感染C-erbB-2表达可作为鉴别胃癌侵袭性的标志物，为进一步治疗提供依据。
BACKGROUND/AIMS
Conflicting results concerning the relationships between abnormal expression of p53 and c-erbB-2 and biologic behavior of gastric cancer are noted. Therefore, overexpression of p53 and c-erbB-2 in relation to the following aspects of gastric cancer: tumor histopathology, Helicobacter pylori infection, and prognosis are explored.
MATERIALS AND METHODS
Expression of p53 and c-erbB-2 by immunohistochemistry was correlated with histopathology, H. pylori infection and prognosis of gastric cancer in 112 patients.
RESULTS
Positive p53 staining was found in 61 (54.5%) of 112 tumors examined. There was no association of p53 expression with sex, age, lymph node metastasis, H. pylori infection or prognosis. A significantly higher frequency of p53-positive staining was observed in advanced (60.7%), intestinal (69.8%) and cardia (76.5%) than in early (30.4%, p < 0.01), diffuse (34.7%, p < 0.01) and noncardia (50.5%, p < 0.05) carcinoma, respectively. Expression of c-erbB-2 was found in 34 cases (30.3%), and was not related to sex, age, H. pylori infection and tumor location. Tumors with positive c-erbB-2 staining appeared to behave more aggressively in view of higher rates of nodal metastasis (38.0% vs 17.1%, p < 0.05), advanced stage (37.1% vs 4.3%, p < 0.01) and poor mean survival (p < 0.01). Patients with intestinal type tumors also had a significantly higher rate of c-erbB-2 expression than those with diffuse tumors (39.7% vs 18.4%, p < 0.01).
CONCLUSIONS
Our results indicate that immunohistochemical expressions of p53 and c-erbB-2 are significantly associated with some histopathological phenotypes. Genetic alterations of c-erbB-2 or p53 may not be affected by H. pylori infection. C-erbB-2 expression may be used as a marker for identifying more aggressive gastric cancer for designing further therapy.