Actin filaments as tension sensors.
Actin filaments as tension sensors.
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DOI：
10.1016/j.cub.2011.12.010
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发表时间：
2012-02-07
期刊：
影响因子：
--
通讯作者：
Egelman EH
中科院分区：
文献类型：
--
作者：
Galkin VE;Orlova A;Egelman EH
机械生物学领域在过去几年中经历了爆炸性的增长，因为人们对理解细胞如何转导机械力以及细胞如何迁移，粘附和产生牵引力的兴趣大大增加。肌动蛋白是一种高度丰富和高度保守的蛋白质，在形成动态细胞骨架中起着重要作用，动态细胞骨架对细胞的形态、运动性和机械敏感性至关重要。虽然肌动蛋白丝（F-肌动蛋白）已被视为动态的聚合和解聚，新的结果表明，F-肌动蛋白本身可能作为一个高度动态的张力传感器。这一特性可能有助于解释肌动蛋白序列的不寻常保守性，并进一步阐明肌动蛋白在从肌节到应力纤维的结构中的重要作用。
The field of mechanobiology has witnessed an explosive growth over the past several years as interest has greatly increased in understanding how mechanical forces are transduced by cells and how cells migrate, adhere and generate traction. Actin, a highly abundant and anomalously conserved protein, plays a large role in forming the dynamic cytoskeleton that is so essential for cell form, motility and mechanosensitivity. While the actin filament (F-actin) has been viewed as dynamic in terms of polymerization and depolymerization, new results suggest that F-actin itself may function as a highly dynamic tension sensor. This property may help explain the unusual conservation of actin’s sequence, as well as shed further light on actin’s essential role in structures from sarcomeres to stress fibers.