Phenotypic determination of epithelial appendages: Genes, developmental pathways, and evolution
Phenotypic determination of epithelial appendages: Genes, developmental pathways, and evolution
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DOI：
10.1038/sj.jidsp.5640235
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发表时间：
1999-12-01
影响因子：
--
通讯作者：
Noveen, A
中科院分区：
文献类型：
--
作者：
Chuong, CM;Noveen, A
上皮附属物是上皮细胞的衍生物，其精心制作以形成专门的结构和功能。附肢可以向外突出，如在牙齿和羽毛中，或内陷，如在腺体中。上皮细胞可以是外胚层的，例如在毛发中，或内胚层的，例如在肝脏中。以羽毛作为上皮附属物的原型，我们研究了形态发生过程中上皮-间充质相互作用的连续阶段所涉及的分子信号。我们认为这些构成了基因网络的基础，可以整合到基因超网络和totinetwork中。因为发育的单位是分子通路而不是单个分子，形态发生的单位是细胞群而不是单个细胞，所以我们将基因/发育通路与单词/句子进行类比。研究上皮附属器器官发生的发育途径有助于我们理解基因的语法和构建受调控的新生长的基本规律。这些知识可能有助于癌症生物学（解除管制的新生长）和器官再生的研究。
Epithelial appendages are derivatives of epithelia that elaborate to form specialized structures and functions. The appendage can protrude out, such as in teeth and feathers, or invaginate in, such as in glands. The epithelia can be ectodermal, such as in hairs, or endodermal, such as in livers. Using feather as a prototype of epithelial appendage, we study the molecular signals involved in the successive stages of epithelial-mesenchymal interactions during morphogenesis. We propose that these form the basics of gene networks, which can be integrated to gene supernetwork and totinetwork, Because the unit of development is molecular pathway rather than single molecule, and the unit of morphogenesis is cell group rather than single cell, we make the analogy between genes/developmental pathways and words/sentences. The study of developmental pathways in epithelial appendage organogenesis will help us to understand the grammar of genes and the basic rules in constructing regulated new growth. This knowledge may contribute to the study of cancer biology (deregulated new growth) and organ regeneration.