Ethnic differences in the incidence of childhood IDDM in Israel (1965-1993) - Marked increase since 1985, especially in Yemenite Jews
Ethnic differences in the incidence of childhood IDDM in Israel (1965-1993) - Marked increase since 1985, especially in Yemenite Jews
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DOI：
10.2337/diacare.20.4.504
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发表时间：
1997-04-01
期刊：
影响因子：
16.2
通讯作者：
Laron, Z
中科院分区：
文献类型：
--
作者：
Shamis, I;Gordon, O;Laron, Z
目的-建立在1965年至1993年期间在不同的种族群体在Israel.Research设计和方法的儿童胰岛素依赖型糖尿病（0-17岁）的发病率的变化在以色列开始在1965年。胰岛素依赖型糖尿病的发作被认为是第一次胰岛素注射的日期。数据收集自所有门诊和医院。估计确诊率超过95%。结果-共有1,868例患者登记了28年。各族裔群体之间存在着明显的差异。发病率最高的是也门犹太人，达到18.5/10（5），其次是德系犹太人（10.0/10（5）），非德系犹太人，除也门人（7.3/10（5））和阿拉伯人（2.9/10（5））。此外，它被发现，在所有的犹太人亚组，与阿拉伯人相比，有一个显着的发病率增加后，1985年。结论-以色列是一个国家，低，中，高发病率的儿童胰岛素依赖型糖尿病。发病率的种族间差异可能是由于遗传因素。然而，自1985年以来，犹太人中的发病率显著增加，这是迄今尚未查明的环境因素造成的。据推测，胰岛素依赖型糖尿病的显著增加是由于与富裕和生活方式的变化有关的环境因素。这也可以解释犹太人和阿拉伯人之间发病率的差异，后者更多地生活在农村地区，生活方式更传统。
OBJECTIVE - To establish the changes in the incidence of childhood IDDM during the years 1965-1993 in the different ethnic groups in Israel.RESEARCH DESIGN AND METHODS - A whole-country register of childhood IDDM (0-17 years) was started in Israel in 1965. Onset of IDDM was considered to be the date of first insulin injection. The data were collected from all outpatient clinics and hospitals. Ascertainment is estimated to be over 95%.RESULTS - A total of 1,868 patients were registered for a period of 28 years. Marked differences were found between ethnic groups. The highest incidence was among the Yemenite Jews, who reached an incidence of 18.5/10(5), followed by Ashkenazi Jews (10.0/10(5)), non-Ashkenazi Jews, except Yemenites (7.3/10(5)), and Arabs (2.9/10(5)). In addition, it was found that in all Jewish subgroups, in contrast with the Arabs, there was a marked increase in incidence after 1985.CONCLUSIONS - Israel is a country with low, intermediate, and high incidence of childhood IDDM. The interethnic differences in incidence are probably due to genetic factors. However, the significant increase in incidence since 1985 in the Jewish population is ascribed to thus far unidentified environmental factors. It is hypothesized that the marked increase in IDDM is due to environmental factors linked to changes in affluence and lifestyle. These may also explain the difference in incidence between the Jewish and Arab populations, the latter living more in rural areas and leading a more traditional lifestyle.