Complexity of the Basic Reproduction Number (R0)
Complexity of the Basic Reproduction Number (R0)
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DOI：
10.3201/eid2501.171901
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发表时间：
2019-01-01
影响因子：
11.8
通讯作者：
Jacobsen, Kathryn H.
中科院分区：
文献类型：
--
作者：
Delamater, Paul L.;Street, Erica J.;Jacobsen, Kathryn H.
基本繁殖数（R-0），也称为基本繁殖率或基本繁殖率，是一种流行病学指标，用于描述传染性或传染性病原体。R-0受许多控制病原体传播的生物、社会行为和环境因素的影响，因此，通常使用各种复杂的数学模型来估计，这使得R-0很容易被误解、误解和误用。R-0不是病原体的生物学常数，也不是随时间变化的速率或疾病严重程度的量度，并且R-0不能通过疫苗接种活动进行修改。R-0很少直接测量，建模的R-0值取决于模型结构和假设。科学文献中报告的一些R-0值可能已经过时。R-0必须非常谨慎地估计、报告和应用，因为这个基本指标远非简单。
The basic reproduction number (R-0), also called the basic reproduction ratio or rate or the basic reproductive rate, is an epidemiologic metric used to describe the contagiousness or transmissibility of infectious agents. R-0 is affected by numerous biological, sociobehavioral, and environmental factors that govern pathogen transmission and, therefore, is usually estimated with various types of complex mathematical models, which make R-0 easily misrepresented, misinterpreted, and misapplied. R-0 is not a biological constant for a pathogen, a rate over time, or a measure of disease severity, and R-0 cannot be modified through vaccination campaigns. R-0 is rarely measured directly, and modeled R-0 values are dependent on model structures and assumptions. Some R-0 values reported in the scientific literature are likely obsolete. R-0 must be estimated, reported, and applied with great caution because this basic metric is far from simple.