Therapeutic Effect of Polidocanol Sclerotherapy on Oral Vascular Malformations.
Therapeutic Effect of Polidocanol Sclerotherapy on Oral Vascular Malformations.
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DOI：
10.3390/dj9100119
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发表时间：
2021-10-14
影响因子：
2.6
通讯作者：
Bukawa H
中科院分区：
文献类型：
--
作者：
Fukuzawa S;Yamagata K;Okubo-Sato M;Terada K;Uchida F;Ishibashi-Kanno N;Bukawa H
各种治疗口腔血管畸形（VM）的报告。聚多卡醇和无水乙醇也被报道用于硬化疗法。但是，关于聚多卡醇硬化剂治疗的疗效和剂量的报道仍然很少。因此，我们研究了其对口腔VM的治疗作用。有17个VM的网站，9名患者在筑波大学医院牙科和口腔外科诊断为口腔VM。回顾性调查病历，以确定部位、血管瘤体积、聚多卡醇注射量和治疗效果。使用磁共振图像计算血管瘤的体积。根据该部位，分别在8例、3例、5例和1例患者的舌、颊粘膜、嘴唇和口底观察到口腔VM。该网站的平均大小为3071立方毫米。聚多卡醇在一个部位的平均注射剂量为2.86 mL，平均给药次数为1.6次，应答率为88.2%。未观察到不良事件。术后第1天和术后1周的中位数字评定量表评分分别为2/10（0-6/10）和0/10（0-1/10）。成功病例总剂量的单变量回归分析提供了以下公式：1.3 + 0.00025 ×体积（mm 3）（mg）。聚多卡醇硬化疗法是治疗口腔VM的有效方法。
Various treatments for oral vascular malformation (VM) have been reported. Polidocanol and absolute ethanol have also been reported for sclerotherapy. However, there are still few reports on the therapeutic effect and dosage of polidocanol sclerotherapy. Therefore, we examined its therapeutic effects on oral VM. There were 17 sites of VMs, with nine patients diagnosed with oral VM at the Department of Dental and Oral Surgery, Tsukuba University Hospital. The medical records were retrospectively investigated to determine the site, hemangioma volume, polidocanol injection volume, and therapeutic effect. The volume of hemangiomas was calculated using magnetic resonance images. Based on the site, oral VMs were observed in the tongue, buccal mucosa, lips, and oral floor in eight, three, five, and one patients, respectively. The average size of the site was 3071 mm3. The average injection dose of polidocanol at one site was 2.86 mL, the average number of administrations was 1.6, and the response rate was 88.2%. No adverse events were observed. The median numerical rating scale scores were 2/10 (0–6/10) and 0/10 (0–1/10) the day after surgery and 1 week after surgery, respectively. Univariate regression analysis of the total dose in successful cases provided the following formula: 1.3 + 0.00025 × volume (mm3) (mg). Polidocanol sclerotherapy is an effective treatment method for oral VM.