GLUCAGON-EVOKED GASTRIC DYSRHYTHMIAS IN HUMANS SHOWN BY AN IMPROVED ELECTROGASTROGRAPHIC TECHNIQUE
GLUCAGON-EVOKED GASTRIC DYSRHYTHMIAS IN HUMANS SHOWN BY AN IMPROVED ELECTROGASTROGRAPHIC TECHNIQUE
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DOI：
10.1016/0016-5085(85)90022-8
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发表时间：
1985-01-01
期刊：
影响因子：
29.4
通讯作者：
MALAGELADA, JR
中科院分区：
文献类型：
--
作者：
ABELL, TL;MALAGELADA, JR
本研究的目的是改善记录技术的识别胃电节律紊乱，并探讨潜在的药物引起胃节律紊乱。健康志愿者（18名）参与了22项单独的记录，分为2项单独的研究-剂量反应研究和随机双盲研究。内部或粘膜胃电图记录了一种新的方法，使用磁力保持内部电极与胃壁并置，而外部或皮肤胃电图，测压活动和呼吸通过常规方法进行测量。同时内部和外部的胃电图信号，包括心律失常和心律失常的时间间隔分析，揭示了内部和外部信号之间的良好对应关系。在剂量反应研究中，静脉输注胰高血糖素（剂量范围为3-22 μ g/kg）的6名志愿者中的5名发生胃电节律障碍。在随机、双盲研究中，静脉输注胰高血糖素（7 μ g/kg）的5名志愿者中有4名发展出胃节律障碍，这是通过改进的技术识别的。通过视觉分析定义的节律障碍包括胃动过速（≥ 100%）和胃动过速（≥ 100%）。≥ 6个循环/分钟1分钟）或胃徐缓（≥ 1分钟）。≥ 1个循环/分钟1分钟），并在内部和外部胃电图上都很明显。心律失常通常与胃窦期压活动的缺失有关，并常伴有恶心。
The objective of this study was to improve recording techniques for the recognition of gastric electrical dysrhythmias, and to explore the potential of pharmacologic agents to evoke gastric dysrhythmias. Healthy volunteers (18) participated in 22 individual recordings, divided into 2 separate studies- a dose-response study and a randomized, double-blind study. The internal or mucosal electrogastrogram was recorded with a novel approach, using magnetic force to maintain internal electrodes in apposition with the gastric wall, whereas the external or cutaneous electrogastrogram, manometric activity, and respiration were measured by conventional methods. Analysis of simultaneous internal and external electrogastrographic signals, including both dysrhythmia and dysrhythmia-free intervals, revealed a good correspondence between the internal and external signals. In the dose-response study, 5 of the 6 volunteers i.v. infused with glucagon, in doses ranging from 3-22 .mu.g/kg, developed gastric electrical dysrhythmias. In the randomized, double-blind study, 4 of 5 volunteers i.v. infused with glucagon (7 .mu.g/kg) developed gastric dysrhythmias that were recognized by the improved techniques. Dysrhythmias, defined by visual analysis, consisted either of tachygastria (.gtoreq. 6 cycles/min for .gtoreq. 1 min) or bradygastria (.gtoreq. 1 cycle/min for .gtoreq. 1 min) and were evident on both internal and external electrogastrograms. Dysrhythmias were usually associated with absence of antral phasic pressure activity and frequently with nausea.