Serologic evidence of active Epstein-Barr virus infection in Epstein-Barr virus-associated lymphoproliferative disorders of children with acquired immunodeficiency syndrome.
Serologic evidence of active Epstein-Barr virus infection in Epstein-Barr virus-associated lymphoproliferative disorders of children with acquired immunodeficiency syndrome.
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获得性免疫缺陷综合征儿童的 Epstein-Barr 病毒相关淋巴细胞增殖性疾病中活动性 Epstein-Barr 病毒感染的血清学证据。
DOI：
10.1016/s0022-3476(05)80432-9
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Shapiro,ED
中科院分区：
文献类型：
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作者：
Katz,BZ;Berkman,AB;Shapiro,ED
在获得性免疫缺陷综合征（AIDS）患者的非霍奇金淋巴瘤（NHL）和淋巴细胞性间质性肺炎（LIP）组织中检测到EB病毒（EBV）的DNA和核抗原。为了确定这些疾病中是否存在活动性EBV感染的血清学证据，我们进行了一项病例对照研究。病例患者为10例获得性免疫缺陷综合征合并EBV基因组阳性肺炎或淋巴瘤的儿童。我们随机选择了一个或两个，如果可用的话，匹配的对照患者与人类免疫缺陷病毒感染的每个索引患者，并比较他们的EBV血清学特征与索引病例患者在活检时。入选10例病例和13例匹配的对照患者。所有10例患者（100%）与13例匹配对照患者中的2例（15%）相比，在索引患者进行活检时有原发性或再活化EBV感染的血清学证据（p<0.001）。因此，我们发现血清学和病毒学证据表明，EB病毒与EB病毒相关的淋巴细胞间质性肺炎和非霍奇金淋巴瘤在儿童获得性免疫缺陷综合征的病因。
The DNA and nuclear antigens of Epstein-Barr virus (EBV) have been detected in specimens of tissue of non-Hodgkin lymphoma and lymphocytic interstitial pneumonitis from patients with acquired immunodeficiency syndrome. To determine whether there is serologic evidence of an active EBV infection in these disorders, we conducted a case-control study. The case patients were 10 children with acquired immunodeficiency syndrome and EBV genome-positive pneumonitis or lymphoma. We randomly selected one or, if available, two matched control patients with human immunodeficiency virus infection for each index patient and compared their EBV serologic profiles with those of the index case patient at the time of the biopsy. Ten case patients and 13 matched control patients were enrolled. All 10 case patients (100%) compared with 2 (15%) of 13 matched control patients had serologic evidence of either a primary or a reactivated EBV infection at the time the index patient had a biopsy performed (p<0.001). Therefore we found serologic and virologic evidence that EBV is etiologically related to EBV-associated lymphocytic interstitial pneumonitis and non-Hodgkin lymphoma in children with acquired immunodeficiency syndrome.