In-vivo transducer to measure dynamic mitral annular forces.
In-vivo transducer to measure dynamic mitral annular forces.
复制标题
用于测量动态二尖瓣环力的体内传感器。
DOI：
10.1016/j.jbiomech.2012.03.009
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发表时间：
2012
影响因子：
2.4
通讯作者：
Yoganathan,AjitP
中科院分区：
文献类型：
--
作者：
Siefert,AndrewW;Jimenez,JorgeH;West,DustinS;Koomalsingh,KevinJ;Gorman,RobertC;Gorman3rd,JosephH;Yoganathan,AjitP
关于作用于植入心脏二尖瓣的器械的力的知识有限。开发一种传感器来测量峰值力大小、时间变化率以及与左心室压力的关系将有助于器械开发。开发了一种新型力传感器，并将其植入绵羊受试者的二尖瓣环中。在心脏停搏后的心脏中，连续测量心动周期的间隔-侧向力和横向力，达到90 mmHg的峰值左心室压力。观察到每个力从心室舒张末期开始增加，并在收缩中期达到峰值。在整个心动周期中，间隔-外侧和横向力的平均变化分别为4.4±0.2N和1.9±0.1N。在等容收缩时，间隔-外侧和横向力分别以143± 8 N/s和34± 9 N/s的峰值速率增加。结合起来，这项研究提供了第一个定量评估的间隔外侧和横向力的收缩二尖瓣环。所开发的传感器是成功的，在测量这些力的方法可以扩展到未来的研究。在进一步调查后，这些数据可能有助于更安全地开发和评价旨在修复或置换二尖瓣功能的器械。
Limited knowledge exists regarding the forces which act on devices implanted to the heart's mitral valve. Developing a transducer to measure the peak force magnitudes, time rates of change, and relationship with left ventricular pressure will aid in device development. A novel force transducer was developed and implanted in the mitral valve annulus of an ovine subject. In the post-cardioplegic heart, septal-lateral and transverse forces were continuously measured for cardiac cycles reaching a peak left ventricular pressure of 90mmHg. Each force was seen to increase from ventricular diastole and found to peak at mid-systole. The mean change in septal-lateral and transverse forces throughout the cardiac cycle was 4.4±0.2N and 1.9±0.1N respectively. During isovolumetric contraction, the septal-lateral and transverse forces were found to increase at peak rate of 143±8N/s and 34±9N/s, respectively. Combined, this study provides the first quantitative assessment of septal-lateral and transverse forces within the contractile mitral annulus. The developed transducer was successful in measuring these forces whose methods may be extended to future studies. Upon additional investigation, these data may contribute to the safer development and evaluation of devices aimed to repair or replace mitral valve function.