The central role of CD4(+) T cells in the antitumor immune response.
The central role of CD4(+) T cells in the antitumor immune response.
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DOI：
10.1084/jem.188.12.2357
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发表时间：
1998-12-21
期刊：
影响因子：
--
通讯作者：
Levitsky H
中科院分区：
文献类型：
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作者：
Hung K;Hayashi R;Lafond-Walker A;Lowenstein C;Pardoll D;Levitsky H
诱导最佳的全身性抗肿瘤免疫涉及对肿瘤相关抗原特异的CD4 +和CD8 + T细胞的启动。CD4 + T辅助细胞（Th）在此反应中的作用在很大程度上归因于为主要组织相容性复合体I类限制性CD8 +细胞毒性T淋巴细胞的启动提供所需的调节信号，这些细胞毒性T淋巴细胞被认为是介导肿瘤杀伤的主要效应细胞。然而，对经转导可分泌粒细胞/巨噬细胞集落刺激因子的照射肿瘤细胞进行疫苗接种所诱导的肿瘤排斥效应阶段的分析表明，CD4 + T细胞在协调宿主对肿瘤的反应中具有更广泛的作用。这种免疫形式导致Th1和Th2反应同时被诱导，这两种反应对于最大程度的全身性抗肿瘤免疫都是必需的。这些CD4 + T细胞产生的细胞因子激活嗜酸性粒细胞以及产生超氧化物和一氧化氮的巨噬细胞。然后这两种细胞类型在肿瘤攻击部位协同作用导致肿瘤破坏。
The induction of optimal systemic antitumor immunity involves the priming of both CD4+ and CD8+ T cells specific for tumor-associated antigens. The role of CD4+ T helper cells (Th) in this response has been largely attributed to providing regulatory signals required for the priming of major histocompatibility complex class I restricted CD8+ cytolytic T lymphocytes, which are thought to serve as the dominant effector cell mediating tumor killing. However, analysis of the effector phase of tumor rejection induced by vaccination with irradiated tumor cells transduced to secrete granulocyte/macrophage colony-stimulating factor indicates a far broader role for CD4+ T cells in orchestrating the host response to tumor. This form of immunization leads to the simultaneous induction of Th1 and Th2 responses, both of which are required for maximal systemic antitumor immunity. Cytokines produced by these CD4+ T cells activate eosinophils as well as macrophages that produce both superoxide and nitric oxide. Both of these cell types then collaborate within the site of tumor challenge to cause its destruction.