Theta-modulated place-by-direction cells in the hippocampal formation in the rat.
Theta-modulated place-by-direction cells in the hippocampal formation in the rat.
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theta修饰的大鼠海马形成中的划分细胞。
DOI：
10.1523/jneurosci.2635-04.2004
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发表时间：
2004-09-22
期刊：
影响因子：
--
通讯作者：
O'Keefe J
中科院分区：
文献类型：
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作者：
Cacucci F;Lever C;Wills TJ;Burgess N;O'Keefe J
我们报道了一类细胞的空间和时间特性，这类细胞被称为theta调制的位置-按方向细胞(TPD)，记录于大鼠的小叶前皮质和旁小叶皮质。将开阔场地中TPD细胞的放电特征与其他两类在海马结构中特征良好的细胞：位置细胞和头部方向细胞进行了比较。位置细胞只编码动物的位置，头部方向细胞只编码动物的方向，而TPD细胞既编码动物的位置，也编码动物的头部方向。它们的放电也受到强烈的调制，主要是在当地记录的theta波的从负到正的阶段放电。TPD的theta调制明显强于Place细胞。相比之下，头部方向细胞的放电完全不受theta的调节。在反复暴露于同一环境中，TPD细胞的位置和方向信号稳定。当在不同的环境中记录时，TPD位置场和方向场可以解耦，位置场不可预测地移动(重新映射)，而其方向偏好在不同环境中保持相似。
We report the spatial and temporal properties of a class of cells termed theta-modulated place-by-direction cells (TPD) recorded from the pre- and parasubicular cortices of the rat. The firing characteristics of TPD cells in open field enclosures were compared to those of two other well-characterised cell classes in the hippocampal formation: place and head-direction cells. Unlike place cells, which code only for the animal's location, or head direction cells which code only for the animal's directional heading, TPD cells code for both the location and the head direction of the animal. Their firing is also strongly modulated, firing primarily at the negative-to-positive phase of the locally recorded theta wave. TPD theta modulation is significantly stronger than that of place cells. By contrast, the firing of head direction cells is not modulated by theta at all. In repeated exposures to the same environment, the locational and directional signals of TPD cells are stable. When recorded in different environments, TPD locational and directional fields can uncouple, with the locational field shifting unpredictably (“remapping”), while its directional preference remains similar across environments.