Meperidine disposition in mother, neonate, and nonpregnant females
Meperidine disposition in mother, neonate, and nonpregnant females
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母亲、新生儿和非妊娠女性的哌替啶分布
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
R. Sokol
中科院分区：
文献类型：
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作者：
B. R. Kuhnert;P. Kuhnert;A. Prochaska;R. Sokol
哌替啶代谢是否受到妊娠或不成熟的影响尚不清楚。这是一个有趣的发现，因为哌替啶通常在分娩时用于缓解疼痛，胎儿在子宫内接受药物。此外，动物研究表明，妊娠激素有助于降低药物代谢酶的活性。本研究采用气相色谱法测定孕妇和非孕妇血浆和尿液以及新生儿尿液中哌替啶和去甲哌替啶的浓度。静脉给药后至少3小时收集血浆样本，计算哌哌啶处置的动力学参数；收集3天尿液样本。与动物实验报告相反，我们发现孕妇和非孕妇很容易将哌替啶代谢为去甲哌替啶，并以相似的方式排出。围生期和未怀孕受试者的动力学常数均无显著差异。发现新生儿代谢和排泄这些药物的速度较慢。
Whether meperidine metabolism is affected by pregnancy or immaturity has not been clearly established. This is of interest because meperidine is commonly given during labor for pain relief and the fetus receives the drug in utero. Moreover, animal studies suggest that the hormones of pregnancy contribute to decreased activity of the drug‐metabolizing enzymes. In our study gas chromatography was used to determine the concentrations of meperidine and normeperidine in the plasma and urine of pregnant and nonpregnant women and in the urine of neonates. Plasma samples were collected for at least 3 hr after a dose of meperidine intravenously to calculate the kinetic parameters of meperidine disposition; urine samples were collected for 3 days. In contrast to reports on animals, we found that pregnant and nonpregnant women readily metabolize meperidine to normeperidine and excrete both in a similar manner. No significant differences were demonstrated between any of the kinetic constants for peripartum and nonpregnant subjects. The neonate was found to metabolize and excrete these drugs less rapidly.