Olestra, a nondigestible, nonabsorbable fat. Effects on gastrointestinal and colonic transit.
Olestra, a nondigestible, nonabsorbable fat. Effects on gastrointestinal and colonic transit.
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奥利斯特拉（Olestra），一种不可消化、不可吸收的脂肪。
DOI：
10.1007/bf01295714
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发表时间：
1993
影响因子：
3.1
通讯作者：
Thomforde,GM
中科院分区：
文献类型：
--
作者：
Aggarwal,AM;Camilleri,M;Phillips,SF;Schlagheck,TG;Brown,ML;Thomforde,GM
Olestra是蔗糖和长链脂肪酸的六酯、七酯和八酯的混合物，是一种不易消化、不可吸收的脂质，其物理性质和味道与天然甘油三酯相似。我们的目的是确定在45克脂肪餐中用高达30克的olestra替代是否会改变胃，小肠和结肠的运输。五组，每组六名健康志愿者，摄入800大卡、22克蛋白质餐，总共含有45克脂质（N=24）或15克脂质（N=6）。在接受45-g脂肪餐的那些中，用olestra代替0、7.5、15和30 g脂质（每组N=6）。15克脂肪餐完全由天然甘油三酯组成。采用双γ照相机放射性成像方法估计胃和小肠转运（膳食中的99 mTc颗粒）和结肠转运（111 In颗粒）。后者是通过将111 In颗粒从一种包被有pH敏感聚合物甲基丙烯酸酯的胶囊中延迟释放来实现的，该胶囊在回肠末端崩解。在五种等量热量的膳食中，胃、小肠或结肠的转运没有差异。有些人在摄入15克olestra后48小时的粪便重量显着增加，但摄入7.5克或30克olestra的受试者的粪便重量与对照组没有差异。我们的结论是，在45克脂肪餐中用高达30克的olestra替代不会显着改变健康受试者的胃肠道转运。
Olestra, the name proposed for the mixture of hexa-, hepta-and octaesters of sucrose and long-chain fatty acids, is a nondigestible, nonabsorbable lipid with physical properties and taste that are similar to those of natural triglycerides. Our aim was to determine whether substitution with up to 30g of olestra in a 45-g fat meal would alter gastric, small bowel, and colonic transit. Five groups, each of six healthy volunteers, ingested 800-kcal, 22-g protein meals containing a total of 45 g of lipid (N=24) or 15 g of lipid (N=6). Among those receiving the 45-g fat meal, 0, 7.5, 15 and 30g of lipid were substituted with olestra (N=6 per group). The 15-g fat meal consisted entirely of natural triglyceride. A dual gamma camera scintigraphic method was used to estimate gastric and small bowel transit (99mTc pellets in the meal) and colonic transit (111In pellets). The latter was achieved by the delayed release of111In pellets from a capsule coated with a pH-sensitive polymer, methacrylate, that disintegrated in the terminal ileum. There were no differences in the gastric, small bowel, or colonic transits of any of the five equicaloric meals. Some individuals had a significantly greater 48-hr stool weight after ingesting 15g of olestra, but stool weights of subjects consuming 7.5 g or 30g of olestra did not differ from controls. We conclude that substitution with olestra of up to 30 g in a 45-g fat meal does not significantly alter gastrointestinal transit in healthy subjects.